Question

Difficulty: MediumDetermining Paragraph-Level Main Ideas

The passage below is adapted from an essay on the history of neuroscience.

Paragraph 1 (lines 1–12)
For nearly a century, a central dogma of neuroscience held that the mature adult brain was entirely incapable of generating new neurons. According to this view, humans are born with a finite number of brain cells, and any subsequent cognitive decline or brain injury is irreversible because the brain lacks the capacity to replenish its neural stock. This belief was largely established by Santiago Ramón y Cajal, the father of modern neuroscience, who famously declared that in adult brains, "the nerve paths are something fixed, ended, immutable; nothing may be regenerated." This dogma dictated the direction of research and medical treatment for decades, discouraging scientists from looking for signs of new cell growth in adult mammals.

Paragraph 2 (lines 13–27)
However, this scientific consensus began to fracture in the 1960s when researcher Joseph Altman utilized autoradiography to detect dividing cells in the brains of adult rats. Altman’s findings suggested that new neurons were indeed being formed in the hippocampus—a region crucial for learning and memory. Despite the evidence, Altman’s work was widely dismissed or ignored by a scientific community deeply wedded to the established belief of an immutable adult brain. It was not until the late 1990s, when Elizabeth Gould and her colleagues demonstrated neurogenesis in adult primates, and subsequent studies confirmed it in humans, that the scientific community finally accepted adult neurogenesis as a biological reality. This paradigm shift has since revolutionized our understanding of brain plasticity and opened new avenues for treating neurodegenerative diseases.

Which of the following statements best captures the main point of Paragraph 2 (lines 13–27)?

  1. A
    The rejection of historical scientific dogmas has paved the way for modern treatments for neurodegenerative diseases.
  2. B
    Joseph Altman utilized autoradiography in the 1960s to prove that new neurons form in the hippocampus of adult rats.
  3. Although early evidence of adult neurogenesis was initially dismissed, subsequent research eventually convinced scientists to accept that the adult brain can generate new cells.Answer
  4. D
    Scientists readily accepted the existence of adult neurogenesis once primate studies proved that brain paths are fixed and immutable.

Answer

Although early evidence of adult neurogenesis was initially dismissed, subsequent research eventually convinced scientists to accept that the adult brain can generate new cells.
The correct answer accurately summarizes Paragraph 2 by explaining that early evidence of adult neurogenesis (Altman's research) was initially rejected, but subsequent work (Gould's studies and human trials) eventually led to the acceptance of adult cell growth.

Step-by-Step Solution

1
Analyze the structure of Paragraph 2 and identify its transition words and overall focus.
The paragraph begins with the transition 'However' and outlines a history: Altman's 1960s discovery of dividing cells was ignored, but late 1990s research on primates and humans finally led the scientific community to accept adult neurogenesis.
Identifying the chronologically structured narrative helps pinpoint the overall message of the paragraph.
2
Differentiate between the paragraph's main idea, supporting details, and passage-level ideas.
The reference to Altman's autoradiography is a supporting detail. The reference to neurodegenerative disease treatment is a global theme. The overall paragraph is about the progression from rejection to acceptance of the concept.
This prevents choosing options that are too narrow (details) or too broad (passage-level themes).
3
Match the summarized main idea with the option that best paraphrases it.
The statement that early evidence was initially dismissed but later research convinced scientists to accept neurogenesis matches the summarized main idea.
Paraphrasing ensures that the correct answer is chosen based on comprehension rather than simple word-matching.

Key Concept

Determining Paragraph-Level Main Ideas
Estimated Time:1m 30s
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