Question

Difficulty: MediumImplicit and Inferred Relationships

Passage

In the late 1940s, Barbara McClintock began studying the inheritance patterns of maize at Cold Spring Harbor. Her meticulous observations of pigment variations in individual kernels led her to identify genetic elements that could physically move within the genome—transposons, or "jumping genes." This notion directly challenged the prevailing paradigm of the genome as a static, linear arrangement of genes, a concept championed by the era's leading geneticists who likened chromosomes to neat strings of beads. Rather than sparking collaborative dialogue, McClintock’s detailed presentations at annual symposia were met with polite silence or outright dismissiveness. Colleagues found her mathematical rigor hard to follow, and the fluidity she proposed seemed too chaotic to fit the orderly models of hereditary transmission then in favor. Sensing the academic isolation, McClintock stopped publishing her research in major journals by 1953, choosing instead to share her findings primarily with a small circle of trusted peers. Decades later, when molecular biologists observed the same transposable elements in bacteria and yeast, the scientific community finally recognized the genius of her early work, culminating in her receiving the Nobel Prize in 1983.

Based on the passage, which of the following best describes the relationship between the prevailing scientific theories of the 1940s and the reception of McClintock’s research?

  1. The mainstream scientific belief in a static genome made researchers resistant to accepting McClintock’s evidence of genome fluidity.Answer
  2. B
    McClintock’s decision to stop publishing in major journals caused her colleagues to embrace the model of chromosomes as strings of beads.
  3. C
    The academic isolation McClintock faced led her to alter her findings to better align with the orderly models of hereditary transmission.
  4. D
    The discovery of transposable elements in bacteria and yeast prompted McClintock’s initial studies of pigment variations in maize.

Answer

The mainstream scientific belief in a static genome made researchers resistant to accepting McClintock’s evidence of genome fluidity.
The passage implies that the scientific establishment's commitment to the prevailing "static, linear" model of the genome made them unreceptive to McClintock's ideas. Because they viewed chromosomes as "orderly" and static like "strings of beads," the fluidity and apparent chaos of transposons did not fit their established theories, leading to their dismissive attitude.

Step-by-Step Solution

1
Identify the prevailing scientific theory of the era described in the text.
The prevailing paradigm was that the genome is a static, linear arrangement of genes, which geneticists compared to neat strings of beads.
This establishes the academic baseline and model that McClintock's findings were up against.
2
Examine how McClintock's colleagues reacted to her presentations.
Her colleagues met her work with polite silence or dismissiveness, viewing her proposed fluidity as too chaotic to fit their orderly models of transmission.
This shows that the reaction was motivated by how poorly her discoveries fit into their existing theoretical framework.
3
Infer the logical relationship between the prevailing belief and the reaction.
Because the scientific community was strongly committed to the static genome model, they were inherently biased against and unable to accept the concept of mobile genetic elements, leading to her academic isolation.
This connects the community's adherence to the old model directly to their rejection of her new model.

Key Concept

Implicit Cause-and-Effect Relationships
Estimated Time:1m 30s
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