Question

Difficulty: HardPharmacological and Parenteral Therapies

A client who is hemodynamically unstable is admitted to the critical care unit. The client's body weight is recorded as 187 lbs187\text{ lbs}. The healthcare provider prescribes a continuous intravenous infusion of norepinephrine at 0.05 mcg/kg/min0.05\text{ mcg/kg/min}. The pharmacy dispenses an intravenous solution containing norepinephrine 4 mg4\text{ mg} in 250 mL250\text{ mL} of 0.9% Sodium Chloride0.9\%\text{ Sodium Chloride}. At what rate should the nurse program the infusion pump? Record your answer in mL/hr\text{mL/hr} and round to the nearest tenth.

Answer: 15.9 mL/hr

Answer

15.9
To accurately program the infusion pump for a weight-based continuous drip, dimensional analysis is used to bridge the ordered dose (0.05 mcg/kg/min0.05\text{ mcg/kg/min}) to the pump setting (mL/hr\text{mL/hr}). The weight is first converted to 85 kg85\text{ kg}. The hourly dose required is 255 mcg/hr255\text{ mcg/hr}. Because the bag contains 4 mg4\text{ mg} (4000 mcg4000\text{ mcg}) in 250 mL250\text{ mL}, the concentration is 16 mcg/mL16\text{ mcg/mL}. Dividing the hourly dose by the concentration yields 15.937515.9375, which rounds appropriately to 15.915.9.

Step-by-Step Solution

1
Convert weight from pounds to kilograms.
187 lbs÷2.2 lbs/kg=85 kg187\text{ lbs} \div 2.2\text{ lbs/kg} = 85\text{ kg}
Weight-based dosing requires the client's weight in kilograms.
2
Calculate the total dose prescribed per minute.
0.05 mcg/kg/min×85 kg=4.25 mcg/min0.05\text{ mcg/kg/min} \times 85\text{ kg} = 4.25\text{ mcg/min}
This establishes the exact amount of medication the client needs every minute.
3
Calculate the total dose required per hour.
4.25 mcg/min×60 min/hr=255 mcg/hr4.25\text{ mcg/min} \times 60\text{ min/hr} = 255\text{ mcg/hr}
Infusion pumps are programmed in mL per hour, so the dose must reflect an hourly rate.
4
Determine the medication concentration in mcg/mL.
4 mg=4000 mcg4\text{ mg} = 4000\text{ mcg}; 4000 mcg÷250 mL=16 mcg/mL4000\text{ mcg} \div 250\text{ mL} = 16\text{ mcg/mL}
The prescribed dose is in micrograms, so the available medication must be converted to match.
5
Calculate the final infusion rate and round to the nearest tenth.
255 mcg/hr÷16 mcg/mL=15.9375 mL/hr255\text{ mcg/hr} \div 16\text{ mcg/mL} = 15.9375\text{ mL/hr}, which rounds to 15.9 mL/hr15.9\text{ mL/hr}.
Dividing the hourly dose by the concentration yields the volume required per hour.

Key Concept

Weight-based complex continuous intravenous infusions.
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