Question

Difficulty: MediumPhysiological Adaptation

A client receiving an initial intravenous dose of ceftriaxone suddenly reports tightness in the throat and severe shortness of breath. The nurse observes facial angioedema and notes a precipitous drop in blood pressure to 82/48 mm Hg. Place the following emergency nursing actions in the correct order of priority, from first to last.

  1. 1Stop the intravenous antibiotic infusion immediately.
  2. 2Assess airway patency and administer high-flow oxygen.
  3. 3Administer intramuscular epinephrine into the anterolateral thigh.
  4. 4Elevate the client's lower extremities.
  5. 5Administer prescribed intravenous diphenhydramine and corticosteroids.

Answer

The correct priority sequence is to stop the antibiotic infusion, assess the airway and provide oxygen, administer intramuscular epinephrine, elevate the lower extremities, and finally administer adjunctive medications.
In acute anaphylaxis, the priority framework relies on removing the inciting agent followed by ABCs (Airway, Breathing, Circulation). Stopping the infusion prevents further antigen load. Securing the airway and applying oxygen addresses the most immediate threat to life (hypoxia). Intramuscular epinephrine is the priority pharmacological intervention to reverse shock and bronchospasm. Elevating the legs supports circulation (blood pressure), and administering secondary drugs like diphenhydramine resolves lingering symptoms and prevents recurrence.

Step-by-Step Solution

1
Stop the intravenous antibiotic infusion immediately.
Further exposure to the allergen is halted.
Removing the trigger is the critical first step to prevent the reaction from worsening.
2
Assess airway patency and administer high-flow oxygen.
Oxygenation is supported while assessing for laryngeal edema.
Airway and Breathing (the 'A' and 'B' in ABCs) take immediate precedence over circulation and medication administration.
3
Administer intramuscular epinephrine into the anterolateral thigh.
Vasoconstriction and bronchodilation are induced.
Epinephrine is the definitive, life-saving medication for anaphylaxis and must be given as soon as airway/breathing are secured.
4
Elevate the client's lower extremities.
Venous return to the central circulation is increased.
This mechanical intervention helps treat the profound hypotension associated with anaphylactic shock.
5
Administer prescribed intravenous diphenhydramine and corticosteroids.
Secondary histamine receptors are blocked and inflammation is reduced.
These are second-line therapies meant to relieve associated symptoms (e.g., hives) and prevent biphasic reactions, not to treat the immediate life threat.

Key Concept

Management of acute anaphylaxis and physiological decompensation requires immediate removal of the trigger followed by adherence to the ABC (Airway, Breathing, Circulation) prioritization framework.
Estimated Time:1m 30s
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