Question

Difficulty: MediumPharmacological and Parenteral Therapies

The healthcare provider prescribes a continuous intravenous (IV) infusion of sodium nitroprusside at 2 mcg/kg/min2 \text{ mcg/kg/min} for a client experiencing a hypertensive emergency. The client's documented weight is 78 kg78 \text{ kg}. The available medication is a 250 mL250 \text{ mL} bag of 5% dextrose in water5\% \text{ dextrose in water} containing 50 mg50 \text{ mg} of sodium nitroprusside. At what rate, in mL/hr\text{mL/hr}, should the nurse set the infusion pump? Record your answer rounded to the nearest whole number.

Answer: 47 mL/hr

Answer

47
To find the correct pump rate, perform a sequential dimensional analysis. First, calculate the total required dose per minute based on weight: 2 mcg/kg/min×78 kg=156 mcg/min2 \text{ mcg/kg/min} \times 78 \text{ kg} = 156 \text{ mcg/min}. Next, convert this to an hourly dose: 156 mcg/min×60 min/hr=9360 mcg/hr156 \text{ mcg/min} \times 60 \text{ min/hr} = 9360 \text{ mcg/hr}. Convert the dose to milligrams to match the supply: 9360 mcg/hr/1000 mcg/mg=9.36 mg/hr9360 \text{ mcg/hr} / 1000 \text{ mcg/mg} = 9.36 \text{ mg/hr}. The concentration of the supplied bag is 50 mg/250 mL=0.2 mg/mL50 \text{ mg} / 250 \text{ mL} = 0.2 \text{ mg/mL}. Finally, dividing the hourly dose by the concentration yields the rate: 9.36 mg/hr/0.2 mg/mL=46.8 mL/hr9.36 \text{ mg/hr} / 0.2 \text{ mg/mL} = 46.8 \text{ mL/hr}. Rounding 46.846.8 to the nearest whole number gives 4747.

Step-by-Step Solution

1
Calculate the required dose in mcg/min\text{mcg/min}.
156 mcg/min156 \text{ mcg/min}
Multiply the prescribed dose (2 mcg/kg/min2 \text{ mcg/kg/min}) by the client's weight (78 kg78 \text{ kg}) to determine the total amount of medication needed per minute.
2
Convert the minute dose to an hourly dose.
9360 mcg/hr9360 \text{ mcg/hr}
Multiply 156 mcg/min156 \text{ mcg/min} by 60 minutes/hour60 \text{ minutes/hour} because infusion pumps are programmed in mL/hr\text{mL/hr}.
3
Convert the dose from micrograms (mcg\text{mcg}) to milligrams (mg\text{mg}).
9.36 mg/hr9.36 \text{ mg/hr}
Divide 9360 mcg/hr9360 \text{ mcg/hr} by 1000 mcg/mg1000 \text{ mcg/mg} to match the unit of the supplied medication.
4
Determine the concentration of the medication in the IV bag.
0.2 mg/mL0.2 \text{ mg/mL}
Divide the total milligrams (50 mg50 \text{ mg}) by the total volume (250 mL250 \text{ mL}) to establish how much medication is in each milliliter of fluid.
5
Calculate the final volume rate in mL/hr\text{mL/hr}.
46.8 mL/hr46.8 \text{ mL/hr}
Divide the required hourly dose (9.36 mg/hr9.36 \text{ mg/hr}) by the concentration (0.2 mg/mL0.2 \text{ mg/mL}) to determine the volume of fluid needed to deliver the correct dose.
6
Round the final answer.
4747
The question explicitly asks for the answer to be rounded to the nearest whole number.

Key Concept

Weight-based continuous intravenous medication dose calculation and pump rate programming.
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