Question

Difficulty: HardPhysiological Adaptation

A client with type 1 diabetes mellitus is admitted to the intensive care unit with diabetic ketoacidosis (DKA). The client is lethargic, exhibits Kussmaul respirations, and reports severe abdominal pain. Initial laboratory results indicate a blood glucose of 610 mg/dL (33.9 mmol/L) and a serum pH of 7.15. The healthcare provider prescribes a comprehensive DKA treatment protocol. Arrange the following nursing interventions in the correct chronological order of implementation.

  1. 1Initiate a rapid intravenous infusion of 0.9% sodium chloride.
  2. 2Verify that the serum potassium level is greater than 3.3 mEq/L (3.3 mmol/L).
  3. 3Begin a continuous intravenous infusion of regular insulin.
  4. 4Add 5% dextrose to the intravenous fluid regimen when blood glucose reaches 250 mg/dL (13.9 mmol/L).
  5. 5Administer the prescribed subcutaneous insulin dose prior to discontinuing the continuous intravenous infusion.

Answer

The correct sequence for managing Diabetic Ketoacidosis is to first initiate fluid resuscitation with 0.9% sodium chloride, verify the potassium level is above 3.3 mEq/L, begin the regular insulin infusion, add 5% dextrose once the glucose level reaches 250 mg/dL, and finally overlap subcutaneous insulin before discontinuing the intravenous insulin infusion.
The priority sequence for diabetic ketoacidosis (DKA) management addresses the most acute life threats first: hypovolemia, electrolyte disturbances, and acidosis. Fluid resuscitation (0.9% sodium chloride) is always the first intervention to restore perfusion. Next, potassium must be verified (> 3.3 mEq/L) before administering insulin to prevent fatal hypokalemia. Following this, regular IV insulin is started to stop ketogenesis and correct the acidosis. Once blood glucose drops to 250 mg/dL, dextrose must be added to IV fluids to prevent hypoglycemia and cerebral edema. Finally, subcutaneous insulin must overlap with the IV infusion to prevent rebound ketoacidosis.

Step-by-Step Solution

1
Prioritize fluid resuscitation
Intravenous 0.9% sodium chloride is administered rapidly.
Severe dehydration from osmotic diuresis requires immediate intravascular volume expansion to maintain tissue perfusion and hemodynamic stability.
2
Assess electrolyte safety
Serum potassium is verified to be > 3.3 mEq/L.
Insulin therapy drives potassium into the cells; starting insulin with profound hypokalemia can cause fatal cardiac dysrhythmias.
3
Initiate insulin therapy
A continuous intravenous infusion of regular insulin is started.
Insulin is required to correct the severe hyperglycemia, stop lipolysis, and reverse the metabolic acidosis.
4
Modify fluid composition based on glucose response
5% dextrose is added when blood glucose decreases to 250 mg/dL (13.9 mmol/L).
Adding dextrose prevents a rapid decline in blood glucose (hypoglycemia) and limits sudden osmotic shifts that cause cerebral edema.
5
Transition to maintenance therapy
Subcutaneous insulin is administered prior to stopping the IV infusion.
An overlap ensures continuous insulin coverage, preventing rebound ketoacidosis when the short-acting IV insulin is discontinued.

Key Concept

Prioritization of Care in Diabetic Ketoacidosis (DKA)
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