Question

Difficulty: MediumPharmacological and Parenteral Therapies

An adult client who recently experienced status epilepticus is prescribed intravenous phenytoin. When administering this medication, which of the following safety interventions must the nurse implement? Select all that apply.

  1. Ensure the administration rate does not exceed 50 mg/min.Answer
  2. Flush the intravenous line with 0.9% sodium chloride before and after the dose.Answer
  3. C
    Prepare the medication as a secondary infusion mixed with 5% dextrose in water (D5W).
  4. Assess the client's blood pressure and electrocardiogram continuously during the infusion.Answer
  5. E
    Delegate the task of monitoring the client's vital signs during the infusion to unlicensed assistive personnel (UAP).
  6. Observe the intravenous insertion site closely for signs of infiltration or tissue necrosis.Answer

Answer

The nurse must ensure the administration rate does not exceed 50 mg/min, flush the IV line with 0.9% sodium chloride before and after the dose, continuously assess the client's blood pressure and ECG, and closely observe the IV insertion site for infiltration.
Intravenous phenytoin requires strict safety protocols due to its alkaline nature and cardiovascular effects. It must be administered at a maximum rate of 50 mg/min and flushed or mixed exclusively with 0.9% sodium chloride to prevent precipitation. Continuous ECG and blood pressure monitoring are essential to detect arrhythmias and hypotension. Additionally, because it is a vesicant, the IV site must be monitored for extravasation to prevent severe tissue necrosis.

Step-by-Step Solution

1
Evaluate the compatibility requirements for intravenous phenytoin administration.
Identify that phenytoin is only compatible with 0.9% sodium chloride and will precipitate in dextrose solutions.
Preventing crystallization in the IV tubing is critical for patient safety and drug efficacy.
2
Determine the safe administration rate and required physiological monitoring.
Recognize that the infusion rate must not exceed 50 mg/min and requires continuous ECG and blood pressure monitoring.
Rapid administration of phenytoin can lead to cardiovascular collapse, severe hypotension, and life-threatening arrhythmias.
3
Assess the delegation and local site monitoring requirements.
Identify that RN-level assessment cannot be delegated to UAP and that the IV site must be closely monitored for extravasation.
Phenytoin is highly alkaline and can cause severe tissue necrosis if it leaks into surrounding tissues.

Key Concept

Intravenous Phenytoin Administration Safety
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