Question

Difficulty: MediumPharmacological and Parenteral Therapies

A client admitted with severe hypotension requires a continuous intravenous (IV) infusion of dopamine. The healthcare provider's prescription is for a dose of 5 mcg/kg/min5 \text{ mcg/kg/min}. The client's current weight is 176 lbs176 \text{ lbs}. The pharmacy provides a premixed IV bag containing 400 mg400 \text{ mg} of dopamine dissolved in 250 mL250 \text{ mL} of 5%5\% dextrose in water (D5W). At what rate, in mL/hr\text{mL/hr}, should the nurse program the continuous IV infusion pump?

  1. A
    24
  2. 15Answer
  3. C
    33
  4. D
    150

Answer

The correct infusion rate is 15 mL/hr15 \text{ mL/hr}.
The correct answer is 1515. To solve this complex calculation, follow these sequential steps: First, convert the client's weight to kilograms (176 lbs÷2.2=80 kg176 \text{ lbs} \div 2.2 = 80 \text{ kg}). Next, find the per-minute microgram dose (5 mcg/kg/min×80 kg=400 mcg/min5 \text{ mcg/kg/min} \times 80 \text{ kg} = 400 \text{ mcg/min}). Then, convert this to an hourly dose (400 mcg×60 minutes=24,000 mcg/hr400 \text{ mcg} \times 60 \text{ minutes} = 24,000 \text{ mcg/hr}). Since the drug is supplied in milligrams, convert micrograms to milligrams (24,000÷1,000=24 mg/hr24,000 \div 1,000 = 24 \text{ mg/hr}). Finally, determine the concentration of the IV bag (400 mg÷250 mL=1.6 mg/mL400 \text{ mg} \div 250 \text{ mL} = 1.6 \text{ mg/mL}) and divide the hourly dose by this concentration to get the final flow rate (24 mg/hr÷1.6 mg/mL=15 mL/hr24 \text{ mg/hr} \div 1.6 \text{ mg/mL} = 15 \text{ mL/hr}).

Step-by-Step Solution

1
Convert the client's weight from pounds to kilograms.
176 lbs÷2.2 lbs/kg=80 kg176 \text{ lbs} \div 2.2 \text{ lbs/kg} = 80 \text{ kg}
Weight-based dosing requires the client's weight to be precisely measured in kilograms.
2
Calculate the required dose in micrograms per minute.
5 mcg/kg/min×80 kg=400 mcg/min5 \text{ mcg/kg/min} \times 80 \text{ kg} = 400 \text{ mcg/min}
This determines the total amount of medication the client requires every minute based on their body weight.
3
Convert the per-minute dose to an hourly dose.
400 mcg/min×60 min/hr=24,000 mcg/hr400 \text{ mcg/min} \times 60 \text{ min/hr} = 24,000 \text{ mcg/hr}
Continuous IV infusion pumps are programmed in hours, not minutes.
4
Convert the hourly dose from micrograms to milligrams.
24,000 mcg÷1,000 mcg/mg=24 mg/hr24,000 \text{ mcg} \div 1,000 \text{ mcg/mg} = 24 \text{ mg/hr}
The available medication is supplied in milligrams, so the units must match before final calculation.
5
Calculate the volume required to deliver the hourly dose based on the available concentration.
24 mg/hr÷(400 mg250 mL)=24 mg/hr÷1.6 mg/mL=15 mL/hr24 \text{ mg/hr} \div \left( \frac{400 \text{ mg}}{250 \text{ mL}} \right) = 24 \text{ mg/hr} \div 1.6 \text{ mg/mL} = 15 \text{ mL/hr}
This provides the final volumetric flow rate needed for the infusion pump.

Key Concept

Weight-based intravenous dosage calculation and unit conversion
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