Question

Difficulty: MediumPharmacological and Parenteral Therapies

A client in cardiogenic shock is prescribed a continuous intravenous (IV) infusion of dobutamine at a rate of 5 mcg/kg/min5 \text{ mcg/kg/min}. The client weighs 80 kg80 \text{ kg}. The pharmacy provides a premixed IV bag containing 500 mg500 \text{ mg} of dobutamine in 250 mL250 \text{ mL} of 5%5\% dextrose in water (D5W). At what rate, in mL/hr\text{mL/hr}, should the nurse program the electronic infusion pump?

  1. 12Answer
  2. B
    24
  3. C
    48
  4. D
    5.5

Answer

The electronic infusion pump should be programmed to 12 mL/hr12 \text{ mL/hr}.
To determine the correct pump rate, the nurse must first calculate the client's specific dose per minute (5 mcg×80 kg=400 mcg/min5 \text{ mcg} \times 80 \text{ kg} = 400 \text{ mcg/min}), convert this to an hourly dose (400 mcg/min×60 minutes=24,000 mcg/hr400 \text{ mcg/min} \times 60 \text{ minutes} = 24,000 \text{ mcg/hr}), and then convert micrograms to milligrams (24 mg/hr24 \text{ mg/hr}). Next, the concentration of the IV bag is determined (500 mg÷250 mL=2 mg/mL500 \text{ mg} \div 250 \text{ mL} = 2 \text{ mg/mL}). Finally, dividing the hourly dose by the concentration yields the correct pump rate (24 mg/hr÷2 mg/mL=12 mL/hr24 \text{ mg/hr} \div 2 \text{ mg/mL} = 12 \text{ mL/hr}).

Step-by-Step Solution

1
Calculate the total required dose per minute based on the client's weight.
5 mcg/kg/min×80 kg=400 mcg/min5 \text{ mcg/kg/min} \times 80 \text{ kg} = 400 \text{ mcg/min}
Critical care vasoactive drips are often weight-based and must be individualized to the client's mass.
2
Convert the per-minute dose to an hourly dose.
400 mcg/min×60 min/hr=24,000 mcg/hr400 \text{ mcg/min} \times 60 \text{ min/hr} = 24,000 \text{ mcg/hr}
Electronic infusion pumps are programmed in mL/hr\text{mL/hr}, so the time unit must match the pump's hourly setting.
3
Convert the required dose from micrograms (mcg) to milligrams (mg).
24,000 mcg/hr÷1,000 mcg/mg=24 mg/hr24,000 \text{ mcg/hr} \div 1,000 \text{ mcg/mg} = 24 \text{ mg/hr}
The supplied medication is measured in milligrams (500 mg500 \text{ mg}). Units must align before calculating the final fluid volume.
4
Calculate the concentration of the supplied IV bag.
500 mg÷250 mL=2 mg/mL500 \text{ mg} \div 250 \text{ mL} = 2 \text{ mg/mL}
This determines the exact amount of active drug contained in each milliliter of the IV fluid.
5
Determine the final infusion pump rate.
24 mg/hr÷2 mg/mL=12 mL/hr24 \text{ mg/hr} \div 2 \text{ mg/mL} = 12 \text{ mL/hr}
Dividing the required hourly dose by the concentration provides the exact volume of fluid the pump must deliver each hour.

Key Concept

Weight-based intravenous continuous infusion calculations and unit conversions.
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