Question

Difficulty: HardPharmacological and Parenteral Therapies

A nurse is caring for a client with a pulmonary embolism who weighs 85.4 kg85.4\text{ kg}. The client is receiving a continuous intravenous heparin infusion. The current infusion rate is 14 units/kg/hr14\text{ units/kg/hr}. The heparin is supplied as 25,000 units25,000\text{ units} in 250 mL250\text{ mL} of 5% dextrose in water.

The client's morning activated partial thromboplastin time (aPTT) is 39 seconds39\text{ seconds}. According to the hospital's weight-based heparin protocol, for an aPTT between 3636 and 44 seconds44\text{ seconds}, the nurse must administer an intravenous bolus of 40 units/kg40\text{ units/kg} and increase the continuous infusion rate by 2 units/kg/hr2\text{ units/kg/hr}.

Calculate the client's new continuous infusion pump rate in mL/hr\text{mL/hr}. (Record your answer using one decimal place.)

Answer: 13.7 mL/hr

Answer

13.7
To safely titrate a heparin infusion based on a protocol, the nurse must first determine the new dose by adding the prescribed increase to the current rate (14 + 2 = 16 units/kg/hr). Next, calculate the total hourly dose using the client's weight (16 units/kg/hr * 85.4 kg = 1366.4 units/hr). The concentration of the IV bag is 100 units/mL (25,000 units / 250 mL). Finally, divide the total hourly units by the concentration to find the pump rate in mL/hr (1366.4 / 100 = 13.664), which rounds to 13.7 mL/hr.

Step-by-Step Solution

1
Determine the new prescribed heparin dose per hour.
14 units/kg/hr + 2 units/kg/hr = 16 units/kg/hr
The protocol requires increasing the continuous infusion rate by 2 units/kg/hr based on the subtherapeutic aPTT result.
2
Calculate the total required units of heparin per hour.
16 units/kg/hr * 85.4 kg = 1366.4 units/hr
The infusion is weight-based, so the per-kg dose must be multiplied by the client's weight.
3
Determine the concentration of the supplied heparin solution.
25,000 units / 250 mL = 100 units/mL
This establishes how many units of medication are in each mL of the IV fluid.
4
Calculate the final infusion pump rate.
1366.4 units/hr / 100 units/mL = 13.664 mL/hr
Dividing the total hourly units by the concentration yields the fluid volume needed per hour.
5
Round the calculated rate to one decimal place.
13.7 mL/hr
The question explicitly requires rounding to one decimal place.

Key Concept

Weight-based heparin protocol titration and IV pump rate calculation
Estimated Time:2m 0s
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