Question

Difficulty: HardPharmacological and Parenteral Therapies

A client receiving continuous total parenteral nutrition (TPN) via a single-lumen peripherally inserted central catheter (PICC) suddenly develops acute pulmonary edema. The client's oxygen saturation drops to 84%84\% on room air, and the nurse auscultates bilateral crackles. The healthcare provider prescribes a stat dose of intravenous furosemide 60 mg60\text{ mg}. The available furosemide concentration is 10 mg/mL10\text{ mg/mL}. Which of the following is the most appropriate action by the nurse?

  1. Insert a peripheral intravenous catheter and administer 6 mL6\text{ mL} of the furosemide solution over 33 to 66 minutes.Answer
  2. B
    Administer 6 mL6\text{ mL} of the furosemide solution directly into the lowest Y-site of the total parenteral nutrition tubing to ensure rapid central circulation.
  3. C
    Pause the total parenteral nutrition, flush the catheter with 0.9%0.9\% sodium chloride, administer 0.6 mL0.6\text{ mL} of furosemide, flush again, and resume the infusion.
  4. D
    Elevate the head of the bed, apply oxygen via a non-rebreather mask, and wait for the oxygen saturation to improve before giving the diuretic.

Answer

The nurse must insert a new peripheral intravenous catheter and administer 6 mL6\text{ mL} of furosemide slowly over 33 to 66 minutes.
The correct action involves three critical safety principles. First, the nurse accurately calculates the dose volume as 6 mL6\text{ mL} (60 mg÷10 mg/mL60\text{ mg} \div 10\text{ mg/mL}). Second, the nurse applies the pharmacological knowledge that furosemide must be administered slowly to prevent ototoxicity, making a 33 to 66-minute push appropriate. Finally, the nurse recognizes that total parenteral nutrition (TPN) requires a strictly dedicated line due to the extreme risk of chemical incompatibility and precipitation. Because the client only has a single-lumen PICC, establishing a new peripheral intravenous catheter is the only safe method to administer the life-saving medication.

Step-by-Step Solution

1
Calculate the correct medication volume.
60 mg60\text{ mg} ordered ÷10 mg/mL\div 10\text{ mg/mL} concentration = 6 mL6\text{ mL} of furosemide.
Accurate dosage calculation is essential to ensure the client receives the therapeutic dose.
2
Determine the safe rate of administration.
The medication should be pushed slowly over 33 to 66 minutes.
Rapid intravenous administration of high-dose furosemide can cause transient or permanent ototoxicity.
3
Evaluate intravenous compatibility and access.
The current single-lumen PICC cannot be used because it is dedicated to total parenteral nutrition.
Total parenteral nutrition requires a strictly dedicated line due to the high risk of chemical incompatibility, precipitation, and infection.
4
Formulate the correct clinical action plan.
Establish a new peripheral intravenous catheter to safely administer the stat diuretic.
A secondary access site allows for immediate treatment of the pulmonary edema without compromising the safety of the central line.

Key Concept

Safe Parenteral Medication Administration and TPN Principles
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