Question

Difficulty: MediumPharmacological and Parenteral Therapies

A nurse is preparing a prescribed intramuscular dose of a medication that is supplied as a dry powder in a sterile vial. The medication requires reconstitution with bacteriostatic water before administration. In what chronological sequence should the nurse perform the following actions to safely prepare the medication?

  1. 1Perform hand hygiene and scrub the rubber stoppers of both the medication and diluent vials with an alcohol swab.
  2. 2Draw an amount of air into the syringe equal to the required diluent volume and inject it into the diluent vial.
  3. 3Withdraw the appropriate volume of diluent into the syringe and inject it into the vial containing the powdered medication.
  4. 4Withdraw the needle and gently roll the medication vial between the palms of the hands until the powder completely dissolves.
  5. 5Scrub the stopper of the medication vial with a new alcohol swab, inject air into the vial, and withdraw the prescribed dose of the reconstituted drug.

Answer

The correct sequence begins with maintaining asepsis by performing hand hygiene and swabbing the stoppers. Next, air is injected into the diluent vial to equalize pressure, allowing the fluid to be withdrawn. The diluent is then injected into the powder, and the vial is gently rolled to dissolve the medication without creating bubbles. Finally, the stopper is cleansed again to safely withdraw the prescribed dose.
The standard procedure for reconstituting medication requires strict aseptic technique and pressure equalization. Cleansing stoppers first prevents contamination. Injecting air into the diluent vial allows for smooth fluid withdrawal. The diluent is then added to the powder, and the vial is rolled gently to mix without creating bubbles. Finally, the reconstituted medication is withdrawn for administration using continued aseptic practices.

Step-by-Step Solution

1
Maintain asepsis by cleansing vials
Sterile entry points are prepared
To prevent the introduction of microorganisms into the medication
2
Inject air into the diluent vial
Positive pressure is created in the vial
To prevent a vacuum and allow for the easy withdrawal of the liquid diluent
3
Transfer diluent to the powder
Diluent and powder are combined
To initiate the dissolving process for the medication
4
Gently roll the vial between palms
Medication is thoroughly dissolved without bubbling
To prevent frothing or air bubbles which can cause inaccurate dosing
5
Cleanse stopper, inject air, and withdraw dose
Final medication dose is ready in the syringe
To safely extract the exact volume needed for administration

Key Concept

Safe Preparation and Reconstitution of Parenteral Medications
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