Question

Difficulty: HardPharmacological and Parenteral Therapies

A client admitted with cardiogenic shock requires hemodynamic support. The healthcare provider prescribes a continuous intravenous infusion of dobutamine at 2.72.7 mcg/kg/min. The client's most recent weight is 209209 lbs. The pharmacy dispenses a premixed IV bag containing dobutamine 500500 mg in 250250 mL of 5%5\% dextrose in water. Calculate the appropriate infusion pump rate in mL/hr. (Round the final answer to the nearest tenth.)

Answer: 7.7 mL/hr

Answer

The infusion pump should be set to 7.7 mL/hr.
The correct infusion rate is calculated by first determining the client's weight in kilograms (209÷2.2=95209 \div 2.2 = 95 kg). The total minute dose is found by multiplying the weight by the ordered dose (95×2.7=256.595 \times 2.7 = 256.5 mcg/min). This minute dose is then multiplied by 6060 to find the hourly dose (256.5×60=15,390256.5 \times 60 = 15,390 mcg/hr). Because the supplied medication is in milligrams, the hourly dose must be converted (15,390÷1,000=15.3915,390 \div 1,000 = 15.39 mg/hr). The concentration of the supplied IV bag is 22 mg/mL (500500 mg ÷250\div 250 mL). Dividing the required hourly dose by the concentration provides the pump rate (15.39÷2=7.69515.39 \div 2 = 7.695 mL/hr). Finally, rounding 7.6957.695 to the nearest tenth yields 7.77.7 mL/hr.

Step-by-Step Solution

1
Convert the client's weight from pounds to kilograms.
209 lbs÷2.2 lbs/kg=95 kg209 \text{ lbs} \div 2.2 \text{ lbs/kg} = 95 \text{ kg}
The medication dosage is prescribed based on kilograms of body weight.
2
Calculate the prescribed dose per minute.
95 kg×2.7 mcg/kg/min=256.5 mcg/min95 \text{ kg} \times 2.7 \text{ mcg/kg/min} = 256.5 \text{ mcg/min}
To determine the total amount of dobutamine the client requires each minute.
3
Convert the dose per minute to the dose per hour.
256.5 mcg/min×60 min/hr=15,390 mcg/hr256.5 \text{ mcg/min} \times 60 \text{ min/hr} = 15,390 \text{ mcg/hr}
Intravenous infusion pumps are programmed in hourly rates (mL/hr).
4
Convert the hourly dose from micrograms (mcg) to milligrams (mg).
15,390 mcg÷1,000 mcg/mg=15.39 mg/hr15,390 \text{ mcg} \div 1,000 \text{ mcg/mg} = 15.39 \text{ mg/hr}
The medication provided by the pharmacy is measured in milligrams, so units must match.
5
Determine the concentration of the provided intravenous solution.
500 mg÷250 mL=2 mg/mL500 \text{ mg} \div 250 \text{ mL} = 2 \text{ mg/mL}
To identify how many milligrams of dobutamine are contained in each milliliter of the fluid.
6
Calculate the final volume to be infused per hour and round to the nearest tenth.
15.39 mg/hr÷2 mg/mL=7.695 mL/hr15.39 \text{ mg/hr} \div 2 \text{ mg/mL} = 7.695 \text{ mL/hr}, which rounds to 7.7 mL/hr7.7 \text{ mL/hr}
Dividing the required hourly dose by the fluid concentration yields the final pump setting.

Key Concept

Weight-based continuous intravenous medication titration requires converting client weight to kilograms, establishing an hourly dosage rate, and applying the supplied medication concentration to determine the final pump setting.
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