Question

Difficulty: MediumPhysiological Adaptation

A nurse is administering a newly prescribed intravenous antibiotic. Ten minutes into the infusion, the client reports severe shortness of breath, a tight feeling in the throat, and dizziness. The client's blood pressure is 82/5082/50 mm Hg and heart rate is 128128 bpm. Arrange the following nursing interventions in the correct order of priority.

  1. 1Stop the intravenous antibiotic infusion immediately.
  2. 2Maintain a patent airway and administer high-flow oxygen.
  3. 3Administer intramuscular epinephrine into the vastus lateralis.
  4. 4Elevate the lower extremities and initiate a rapid intravenous fluid bolus.
  5. 5Administer adjunctive intravenous diphenhydramine and corticosteroids.

Answer

The correct sequence is to stop the triggering agent, secure the airway and provide oxygen, administer the first-line medication (epinephrine), support circulation with positioning and fluids, and finally administer adjunctive medications.
In any medical emergency involving a continuous intravenous triggering agent, the first and most critical action is to stop the infusion. Following this, the nurse must adhere to the ABC (Airway, Breathing, Circulation) framework. Ensuring a patent airway and providing oxygen addresses the most immediate threat to life (laryngeal edema and hypoxia). Once the airway is supported, intramuscular epinephrine is the absolute priority pharmacological intervention, as it directly reverses bronchospasm and severe vasodilation. After epinephrine administration, circulatory support is provided through leg elevation and rapid isotonic fluid boluses to treat distributive shock. Finally, adjunctive medications such as antihistamines and corticosteroids are administered to alleviate ongoing symptoms and prevent biphasic allergic reactions.

Step-by-Step Solution

1
Identify the immediate threat and remove the cause.
The intravenous antibiotic infusion is stopped immediately.
Halting the exposure to the allergen prevents the anaphylactic reaction from rapidly worsening.
2
Apply the Airway, Breathing, Circulation (ABC) prioritization framework.
A patent airway is maintained, and high-flow oxygen is administered.
Hypoxia and complete airway occlusion from laryngeal edema represent the most immediate threats to life.
3
Administer life-saving primary pharmacotherapy.
Intramuscular epinephrine is administered into the vastus lateralis.
Epinephrine directly counteracts anaphylaxis by causing rapid bronchodilation and vasoconstriction, thereby improving the airway and blood pressure.
4
Manage the profound distributive shock (Circulation).
The lower extremities are elevated, and a rapid intravenous fluid bolus is initiated.
Anaphylaxis causes massive vasodilation and capillary leak. Positioning and volume replacement help restore adequate venous return and systemic perfusion.
5
Administer secondary supportive treatments.
Intravenous diphenhydramine and corticosteroids are administered.
These adjunctive medications block further histamine release and reduce inflammation, helping to prevent a delayed biphasic reaction.

Key Concept

Prioritization of clinical interventions in acute anaphylactic shock utilizing the ABC framework.
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