Question

Difficulty: MediumPharmacological and Parenteral Therapies

A client on the cardiac step-down unit requires a continuous intravenous infusion of procainamide to manage ventricular ectopy. The healthcare provider's prescription is for 2 mg/min2 \text{ mg/min}. The available premixed solution contains 2 g2 \text{ g} of procainamide in 500 mL500 \text{ mL} of 5%5\% dextrose in water. Calculate the required infusion rate in mL/hr\text{mL/hr}.

Answer: 30 mL/hr

Answer

The correct infusion rate is 30 mL/hr.
To determine the correct infusion rate, the nurse must first align all units of measurement. The provided medication is in grams (2 g2 \text{ g}), which converts to 2000 mg2000 \text{ mg}. The concentration is then found by dividing 2000 mg2000 \text{ mg} by the volume of 500 mL500 \text{ mL}, yielding 4 mg/mL4 \text{ mg/mL}. Next, the prescribed dose of 2 mg/min2 \text{ mg/min} is multiplied by 60 minutes60 \text{ minutes} to determine the hourly requirement of 120 mg/hr120 \text{ mg/hr}. Finally, dividing the hourly requirement (120 mg/hr120 \text{ mg/hr}) by the concentration (4 mg/mL4 \text{ mg/mL}) gives the correct infusion rate of 30 mL/hr30 \text{ mL/hr}.

Step-by-Step Solution

1
Convert the total drug amount from grams to milligrams.
2 g×1000 mg/g=2000 mg2 \text{ g} \times 1000 \text{ mg/g} = 2000 \text{ mg}
The prescribed dose is in milligrams, so the available medication must be converted to the same unit before calculating.
2
Calculate the concentration of the available intravenous solution.
2000 mg/500 mL=4 mg/mL2000 \text{ mg} / 500 \text{ mL} = 4 \text{ mg/mL}
Determining how many milligrams are in each milliliter is necessary to find the fluid volume needed per dose.
3
Convert the prescribed per-minute dose to an hourly dose.
2 mg/min×60 min/hr=120 mg/hr2 \text{ mg/min} \times 60 \text{ min/hr} = 120 \text{ mg/hr}
The final pump rate must be programmed in hours (mL/hr), so the hourly medication requirement must be found.
4
Calculate the final infusion rate by dividing the hourly dose by the concentration.
120 mg/hr/4 mg/mL=30 mL/hr120 \text{ mg/hr} / 4 \text{ mg/mL} = 30 \text{ mL/hr}
This yields the total volume of fluid that must be infused over one hour to deliver the prescribed milligrams.

Key Concept

Calculating continuous intravenous infusion rates (mL/hr) based on weight-independent dosage (mg/min).
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