Question

Difficulty: MediumPharmacological and Parenteral Therapies

A mechanically ventilated client in the intensive care unit requires continuous sedation. The healthcare provider's order reads: dexmedetomidine 0.8 mcg/kg/hr0.8\text{ mcg/kg/hr} continuous IV infusion. The client weighs 154 lb154\text{ lb}. The pharmacy dispenses a pre-mixed solution containing 200 mcg200\text{ mcg} of dexmedetomidine in 50 mL50\text{ mL} of 0.9%0.9\% sodium chloride.

At what rate, in mL/hr\text{mL/hr}, should the infusion pump be programmed? Record your answer using a whole number.

Answer: 14 mL/hr

Answer

14
To determine the correct infusion rate, first convert the client's weight to kilograms (154÷2.2=70 kg154 \div 2.2 = 70\text{ kg}). Next, calculate the prescribed hourly dose by multiplying the weight by the ordered rate (70×0.8=56 mcg/hr70 \times 0.8 = 56\text{ mcg/hr}). Then, find the concentration of the supplied IV bag by dividing the total micrograms by the total milliliters (200 mcg÷50 mL=4 mcg/mL200\text{ mcg} \div 50\text{ mL} = 4\text{ mcg/mL}). Finally, divide the required hourly dose by the concentration to find the pump rate (56÷4=14 mL/hr56 \div 4 = 14\text{ mL/hr}). Since 14 is already a whole number, no rounding is necessary.

Step-by-Step Solution

1
Convert the client's weight from pounds to kilograms.
154 lb÷2.2 lb/kg=70 kg154\text{ lb} \div 2.2\text{ lb/kg} = 70\text{ kg}
The medication dosing is weight-based and requires the weight to be in kilograms.
2
Calculate the total required hourly dose of dexmedetomidine.
70 kg×0.8 mcg/kg/hr=56 mcg/hr70\text{ kg} \times 0.8\text{ mcg/kg/hr} = 56\text{ mcg/hr}
This establishes the exact amount of medication the client needs to receive every hour.
3
Determine the concentration of the supplied dexmedetomidine solution.
200 mcg÷50 mL=4 mcg/mL200\text{ mcg} \div 50\text{ mL} = 4\text{ mcg/mL}
Finding the concentration is necessary to convert the ordered dose in micrograms into a liquid volume in milliliters.
4
Calculate the final infusion rate.
56 mcg/hr÷4 mcg/mL=14 mL/hr56\text{ mcg/hr} \div 4\text{ mcg/mL} = 14\text{ mL/hr}
This determines the exact volumetric rate to program into the intravenous infusion pump.

Key Concept

Weight-based continuous IV infusion calculation
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