Question

Difficulty: MediumPharmacological and Parenteral Therapies

A nurse is caring for a client with a pulmonary embolism who is receiving a continuous heparin infusion through a single peripheral IV catheter. The healthcare provider has newly prescribed intermittent IV vancomycin to treat a concurrent cellulitis infection. Which of the following actions should the nurse take to safely administer these therapies? Select all that apply.

  1. Insert a new, separate peripheral IV catheter to administer the vancomycin infusion.Answer
  2. B
    Connect the vancomycin infusion directly to the lowest Y-site port on the primary heparin tubing.
  3. Verify the client's most recent serum creatinine level and vancomycin trough results before initiating the infusion.Answer
  4. D
    Pause the continuous heparin infusion for 90 minutes to allow the vancomycin to infuse, then resume the heparin.
  5. Assess the new IV insertion site for blood return and absence of swelling prior to starting the antibiotic.Answer
  6. F
    Determine the vancomycin pump setting in mL/hr by dividing the ordered dose in milligrams by the prescribed infusion time in hours.

Answer

The correct actions are inserting a separate IV catheter for the vancomycin, verifying serum creatinine and trough levels, and assessing the new IV site for patency prior to administration.
Safe administration of vancomycin requires monitoring for nephrotoxicity (by checking creatinine and trough levels) and preventing tissue necrosis by confirming IV patency, as it is a vesicant. Because vancomycin and heparin are physically incompatible, and pausing heparin in a client with a pulmonary embolism is unsafe, a separate IV line must be established for the antibiotic.

Step-by-Step Solution

1
Analyze the compatibility of the prescribed intravenous medications.
Vancomycin and heparin are physically incompatible and cannot share the same IV line.
Administering incompatible medications together causes crystallization and precipitation, which can occlude the catheter or cause an embolism.
2
Evaluate the clinical priority of the continuous heparin infusion.
The continuous heparin infusion must not be interrupted to accommodate the antibiotic.
The client has an active pulmonary embolism; stopping the heparin for an extended period drastically decreases therapeutic anticoagulation levels and risks clot extension.
3
Identify the critical safety assessments specific to vancomycin administration.
The nurse must verify renal function (creatinine/troughs) and establish a new, patent IV site.
Vancomycin is both nephrotoxic and a vesicant, requiring strict monitoring of kidney function and vein patency to prevent acute kidney injury and severe tissue damage.

Key Concept

Safe parenteral medication administration requires verifying Y-site compatibility, prioritizing the maintenance of critical continuous infusions, and monitoring for specific drug toxicities such as nephrotoxicity and tissue extravasation.
Estimated Time:1m 30s
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