Question

Difficulty: MediumPharmacological and Parenteral Therapies

A critical care team is managing a client with a severe hypertensive emergency, presenting with a blood pressure of 210/120 mm Hg210/120 \text{ mm Hg}. Because sodium nitroprusside can cause profound hypotension, it must be administered via a controlled infusion pump. The primary healthcare provider orders a continuous intravenous infusion starting at 4 mcg/kg/min4 \text{ mcg/kg/min}. The medication arrives from the pharmacy as a solution containing 100 mg100 \text{ mg} of sodium nitroprusside diluted in 100 mL100 \text{ mL} of normal saline. The client weighs 87 kg87 \text{ kg}.

Calculate the infusion pump rate in mL/hr\text{mL/hr}. Round the final answer to the nearest tenth.

Answer: 20.9 mL/hr

Answer

The infusion pump should be programmed to 20.9 mL/hr20.9 \text{ mL/hr}.
To determine the correct IV pump rate, first calculate the total micrograms required per minute by multiplying the dose by the client's weight (4×87=348 mcg/min4 \times 87 = 348 \text{ mcg/min}). Next, convert this to an hourly rate (348×60=20,880 mcg/hr348 \times 60 = 20,880 \text{ mcg/hr}). Then, find the concentration of the IV solution in micrograms by converting 100 mg100 \text{ mg} to 100,000 mcg100,000 \text{ mcg}, which yields 1000 mcg/mL1000 \text{ mcg/mL}. Finally, divide the required hourly dose by the concentration (20,880÷1000=20.8820,880 \div 1000 = 20.88) and round to the nearest tenth to get 20.9 mL/hr20.9 \text{ mL/hr}.

Step-by-Step Solution

1
Calculate the total mcg required per minute.
4 mcg/kg/min×87 kg=348 mcg/min4 \text{ mcg/kg/min} \times 87 \text{ kg} = 348 \text{ mcg/min}
The prescription is weight-based, so the ordered dose must be multiplied by the client's weight in kilograms.
2
Convert the per-minute dose to an hourly dose.
348 mcg/min×60 min/hr=20,880 mcg/hr348 \text{ mcg/min} \times 60 \text{ min/hr} = 20,880 \text{ mcg/hr}
Infusion pumps are programmed in mL per hour, requiring a time conversion from minutes to hours.
3
Determine the concentration of the medication in mcg/mL.
100 mg=100,000 mcg100 \text{ mg} = 100,000 \text{ mcg}. Concentration = 100,000 mcg÷100 mL=1000 mcg/mL100,000 \text{ mcg} \div 100 \text{ mL} = 1000 \text{ mcg/mL}.
The unit of measurement for the dose (mcg) must match the unit used for the solution concentration to accurately calculate volume.
4
Calculate the final infusion rate.
20,880 mcg/hr÷1000 mcg/mL=20.88 mL/hr20,880 \text{ mcg/hr} \div 1000 \text{ mcg/mL} = 20.88 \text{ mL/hr}. Rounded to the nearest tenth: 20.9 mL/hr20.9 \text{ mL/hr}.
Dividing the hourly dose by the concentration yields the fluid volume to be infused per hour.

Key Concept

Weight-based critical care medication continuous infusion rate calculations (mcg/kg/min to mL/hr)
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