Question

Difficulty: MediumPharmacological and Parenteral Therapies

A nurse is providing care for a client who is receiving total parenteral nutrition (TPN) via a central venous access device. Which of the following nursing actions are necessary to ensure the safe administration of this therapy? Select all that apply.

  1. Monitor capillary blood glucose levels every 4 to 6 hours.Answer
  2. B
    Increase the infusion rate to catch up if the volume falls behind the prescribed schedule.
  3. Replace the intravenous administration set and filter every 24 hours.Answer
  4. D
    Administer scheduled intravenous push medications through the designated TPN port.
  5. Hang an infusion of 10% dextrose in water if the current TPN bag empties before a replacement is available.Answer

Answer

The correct actions include monitoring blood glucose every 4 to 6 hours, replacing the IV tubing and filter every 24 hours, and hanging 10% dextrose in water if the TPN bag runs out early.
Total parenteral nutrition requires meticulous nursing management to prevent metabolic and infectious complications. Because of the high dextrose content, routine capillary blood glucose checks (usually every 4 to 6 hours) are mandatory to monitor for hyperglycemia. If the TPN infusion is interrupted or runs dry before the pharmacy provides the next bag, the nurse must infuse 10% dextrose in water (D10W) at the prescribed TPN rate to prevent profound rebound hypoglycemia. Finally, due to the high risk of microbial growth in the nutrient-rich solution, the IV tubing and inline filter must be completely replaced every 24 hours.

Step-by-Step Solution

1
Evaluate the risk of hyperglycemia and hypoglycemia associated with TPN.
Identify that blood glucose monitoring is required every 4-6 hours, and D10W must be hung if the TPN is interrupted to prevent rebound hypoglycemia.
TPN contains a high concentration of dextrose, which stresses the pancreas. Abrupt cessation removes the glucose source while insulin levels remain temporarily high.
2
Evaluate the infection risks associated with TPN administration.
Identify that the administration set and filter must be changed every 24 hours.
The nutrient-dense nature of TPN promotes rapid microbial growth, necessitating frequent tubing changes according to facility protocol and CDC guidelines.
3
Evaluate line compatibility and flow rate rules for TPN.
Identify that rates should never be sped up to catch up, and the line must remain dedicated solely to TPN.
Speeding up the rate causes hyperosmolar diuresis. Using the TPN line for other medications introduces the risk of dangerous precipitates and compromises line sterility.

Key Concept

Total Parenteral Nutrition (TPN) Safety and Administration Principles
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