A 24-year-old male with no significant past medical history is undergoing an elective open reduction and internal fixation of a right clavicle fracture. Induction of general anesthesia is achieved with propofol and succinylcholine, and anesthesia is maintained with sevoflurane. Thirty minutes into the procedure, the anesthesiologist notes a sudden and abrupt rise in the end-tidal carbon dioxide () to . The patient develops generalized muscle rigidity, most notably in the masseter muscles. His core body temperature begins to rise rapidly and is currently (). His heart rate is , and blood pressure is .
Arrange the following management steps in the most appropriate chronological priority order for this patient's acute perioperative complication.
- 1Discontinue the administration of sevoflurane and succinylcholine.
- 2Hyperventilate the patient with 100% oxygen using high fresh gas flow rates.
- 3Administer intravenous dantrolene.
- 4Administer intravenous calcium chloride, regular insulin, and dextrose.