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Difficulty: EasyGynecologic Oncology

Match each gynecologic or gestational neoplasm with its characteristic clinical tumor marker and classic histologic or clinical finding.

  • Yolk sac (endodermal sinus) tumorMarkedly elevated alpha-fetoprotein (AFP) and presence of Schiller-Duval bodies
  • Granulosa cell tumorSecretes estrogen and inhibin; histology shows Call-Exner bodies
  • ChoriocarcinomaMarkedly elevated beta-hCG; highly aggressive hematogenous spread to lungs
  • DysgerminomaElevated lactate dehydrogenase (LDH); histology shows uniform "fried egg" cells

Answer

Yolk sac tumor matches with elevated AFP; Granulosa cell tumor matches with estrogen, inhibin, and Call-Exner bodies; Choriocarcinoma matches with elevated beta-hCG and lung metastasis; Dysgerminoma matches with elevated LDH and 'fried egg' cells.
Correct matching pairs the neoplasm with its unique pathognomonic diagnostic feature: AFP/Schiller-Duval bodies for yolk sac tumors, estrogen/inhibin/Call-Exner bodies for granulosa cell tumors, beta-hCG/lung metastasis for choriocarcinomas, and LDH/'fried egg' cells for dysgerminomas.

Step-by-Step Solution

1
Identify the characteristic tumor marker and histology for Yolk sac tumors.
Yolk sac tumors are associated with elevated AFP and Schiller-Duval bodies.
These are the primary diagnostic hallmarks of endodermal sinus tumors.
2
Identify the characteristic tumor marker and histology for Granulosa cell tumors.
Granulosa cell tumors secrete estrogen/inhibin and have Call-Exner bodies.
As sex cord-stromal tumors, they produce sex hormones, presenting differently from germ cell tumors.
3
Identify the characteristic tumor marker and clinical presentation for Choriocarcinoma.
Choriocarcinoma presents with markedly elevated beta-hCG and aggressive hematogenous spread to the lungs.
It is a malignant tumor of trophoblastic tissue that readily invades blood vessels.
4
Identify the characteristic tumor marker and histology for Dysgerminomas.
Dysgerminomas are associated with elevated LDH and uniform 'fried egg' cells.
This tumor is the ovarian counterpart to testicular seminoma and shares identical histologic features.

Key Concept

Ovarian and Gestational Tumor Markers and Histopathology
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Topics

Gynecologic Oncology

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