Question

Difficulty: MediumPediatric Hematology and Oncology

A 33-year-old boy is brought to the pediatrician's office by his father, who noticed a firm, painless swelling on the right side of the child's abdomen while dressing him. The child has been eating well, is as active as usual, and has had no fever, vomiting, or bone pain. Vital signs are within normal limits for age, except for a blood pressure of 120/78120/78 mmHg (which is >95>95 th percentile for his age). On physical examination, a smooth, firm, non-tender mass is palpated in the right upper and lower quadrants; it does not cross the midline. The remainder of the examination is unremarkable. Urinalysis reveals 1010-1515 red blood cells per high-power field. Which of the following is the most appropriate next step in the evaluation of this patient?

  1. A
    Computed tomography of the abdomen with contrast
  2. B
    Measurement of urinary homovanillic acid and vanillylmandelic acid
  3. Abdominal ultrasonographyAnswer
  4. D
    Percutaneous core needle biopsy of the mass
  5. E
    Observation and repeat physical examination in 4 weeks

Answer

Abdominal ultrasonography
The correct answer is abdominal ultrasonography. This patient's presentation of a unilateral, painless, firm abdominal mass that does not cross the midline, accompanied by hypertension and microscopic hematuria, is highly suspicious for a Wilms tumor (nephroblastoma). The most appropriate initial step in the evaluation of a pediatric abdominal mass is an ultrasound. It is a rapid, non-invasive imaging modality that avoids ionizing radiation. Ultrasonography can confirm the presence of a mass, differentiate between cystic (e.g., hydronephrosis) and solid structures, and identify the organ of origin (e.g., intrinsic renal mass versus an extrinsic mass like neuroblastoma), which effectively guides the next steps in management and staging.

Step-by-Step Solution

1
Identify the most likely diagnosis based on the clinical presentation.
The patient's age, presence of an asymptomatic unilateral abdominal mass, hypertension, and microscopic hematuria strongly suggest a Wilms tumor (nephroblastoma).
Wilms tumor is the most common pediatric renal malignancy and classically presents with an asymptomatic abdominal mass that does not cross the midline, often accompanied by secondary effects of renal involvement like renin-mediated hypertension and hematuria.
2
Determine the most appropriate initial diagnostic test.
Abdominal ultrasonography is the standard first step.
Ultrasound is a rapid, safe, radiation-free imaging modality that can immediately confirm the mass, distinguish between cystic and solid structures, and verify its origin within the kidney.

Key Concept

Wilms tumor presentation and initial diagnostic workup
Estimated Time:1m 0s
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