A clinical guideline committee is creating a quick-reference protocol for managing specific infectious disease exposures. Match each patient scenario with the single most appropriate pharmacological management plan.
- A 28-year-old healthcare worker who sustained a deep needlestick injury after drawing blood from an untreated patient with a high HIV viral load.Three-drug antiretroviral therapy (e.g., tenofovir, emtricitabine, dolutegravir) for 28 days
- A 32-year-old pregnant woman in active labor whose rectovaginal screening swab at 36 weeks gestation was positive for Streptococcus agalactiae.Intravenous penicillin G administered immediately and repeatedly until delivery
- A 19-year-old college student who shared drinks with a roommate recently hospitalized for confirmed Neisseria meningitidis meningitis.Single oral dose of ciprofloxacin
- A 45-year-old postal worker presenting with a deep puncture wound on the right hand after being bitten by a stray cat.Oral amoxicillin-clavulanate for 3 to 5 days
Answer
Match the HIV exposure to triple ART, the GBS colonization to IV Penicillin G, the meningococcal contact to single-dose ciprofloxacin, and the cat bite to amoxicillin-clavulanate.
Each clinical scenario presents a classic, high-yield infectious exposure with a highly standardized prophylactic or empiric regimen dictated by current infectious disease guidelines. Recognizing these direct associations is fundamental to providing safe and effective urgent care.
Step-by-Step Solution
Key Concept
Post-exposure prophylaxis and targeted empiric therapy for common infectious exposures