Question

Difficulty: MediumChildhood and Neurodevelopmental Disorders

Match each clinical presentation to the most appropriate neurodevelopmental or behavioral psychiatric diagnosis.

  • Parents of a 3-year-old boy note that he rarely makes eye contact, does not engage in pretend play, and becomes extremely distressed if his daily routine is altered.Autism spectrum disorder
  • A 10-year-old boy is evaluated after school suspension. He frequently initiates physical fights, was caught stealing from lockers, and recently set fire to a trash can on school property.Conduct disorder
  • A 7-year-old girl is often touchy and easily annoyed by others. She frequently argues with her teachers and actively defies their requests, but she has never been physically aggressive or destroyed property.Oppositional defiant disorder
  • A 5-year-old girl who met all early developmental milestones began to experience a regression in spoken language and purposeful hand use around 18 months of age, now demonstrating constant hand-wringing movements.Rett syndrome

Answer

The correct matches align the 3-year-old boy with autism spectrum disorder, the 10-year-old boy with conduct disorder, the 7-year-old girl with oppositional defiant disorder, and the 5-year-old girl with Rett syndrome.
Each vignette provides pathognomonic or highly characteristic features for its respective disorder: autism spectrum disorder (social deficits and rigid routines), conduct disorder (severe rights violations like fire-setting), oppositional defiant disorder (defiance without severe aggression), and Rett syndrome (developmental regression with characteristic hand-wringing).

Step-by-Step Solution

1
Analyze the clinical features of the 3-year-old boy.
He demonstrates deficits in social communication and restricted, repetitive patterns of behavior.
Identifying these core symptom domains satisfies the diagnostic criteria for autism spectrum disorder.
2
Evaluate the behavioral patterns of the 10-year-old boy.
His behaviors include aggression toward people, theft, and deliberate destruction of property (fire-setting).
These severe violations of basic rights and societal norms distinguish conduct disorder from milder behavioral issues.
3
Assess the presentation of the 7-year-old girl.
She exhibits defiance and argumentativeness without engaging in severe acts of physical violence or property destruction.
This establishes the diagnosis of oppositional defiant disorder, ruling out the more severe conduct disorder.
4
Review the developmental trajectory of the 5-year-old girl.
She had a period of normal development followed by neurodevelopmental regression and the onset of stereotypic midline hand movements.
This classic temporal sequence and specific motor symptom profile uniquely identify Rett syndrome.

Key Concept

Accurate diagnosis of childhood behavioral and neurodevelopmental disorders requires distinguishing between specific symptom domains, severity of rule violations, and the presence or absence of developmental regression.
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