Match each patient presenting with major depressive disorder to the most appropriate first-line pharmacologic treatment based on their specific comorbidities and symptom profile.
- A 62-year-old man seeking psychiatric treatment one month after an acute myocardial infarction.Sertraline
- A 34-year-old man exhibiting severe fatigue, hypersomnolence, and expressing a strong desire to quit smoking.Bupropion
- A 28-year-old woman suffering from severe insomnia, poor appetite, and unwanted weight loss over the past two months.Mirtazapine
- A 41-year-old woman who has a history of poorly controlled diabetes and complains of burning, painful peripheral neuropathy.Duloxetine
Answer
Match the post-MI patient to Sertraline, the fatigued smoker to Bupropion, the patient with insomnia and weight loss to Mirtazapine, and the diabetic neuropathy patient to Duloxetine.
Each correct match utilizes the unique pharmacokinetic and pharmacodynamic properties of the antidepressants to simultaneously treat the patient's major depressive disorder and their specific comorbid symptoms, optimizing the therapeutic response while minimizing adverse effects.
Step-by-Step Solution
Key Concept
Tailoring antidepressant therapy based on side-effect profiles and medical comorbidities.