An infant boy born at weeks of gestation is currently days old and recovering in the neonatal intensive care unit. Over the past hours, the nursing staff has reported increased episodes of apnea, bradycardia, and a drop in body temperature. The patient had previously been tolerating slowly advancing orogastric feeds, but a large bilious residual was aspirated prior to his last scheduled feed. On evaluation, his temperature is (), blood pressure is , pulse is , and respirations are . Physical examination reveals a lethargic and mottled neonate. His abdomen is markedly distended, firm, and diffusely tender, with prominent erythema spreading across the abdominal wall. Laboratory analysis demonstrates a leukocyte count of with band forms, a platelet count of , and a serum lactate level of . A supine abdominal radiograph shows diffusely dilated loops of bowel, branching linear lucencies overlying the right upper quadrant, and a prominent radiolucent outline of the falciform ligament. Intravenous fluid resuscitation, broad-spectrum antimicrobial therapy, and bowel rest (NPO) are promptly initiated. Which of the following is the most appropriate next step in the management of this patient?
- AComputed tomography scan of the abdomen
- BContinuation of current medical management with serial abdominal radiographs
- CEscalation of antimicrobial therapy to cover fungal pathogens
- Exploratory laparotomyAnswer
- EDiagnostic water-soluble contrast enema