Match each characteristic histological or clinical presentation of a gynecologic neoplasm with its most closely associated serum tumor marker.
- An ovarian neoplasm characterized by sheets of uniform cells with clear cytoplasm and central nuclei, separated by fibrous septa containing a lymphocytic infiltrate.Lactate dehydrogenase (LDH)
- An aggressive germ cell tumor characterized histologically by Schiller-Duval bodies, which are papillary structures resembling primitive glomeruli.Alpha-fetoprotein (AFP)
- A malignant epithelial ovarian tumor frequently presenting with bilateral complex cystic masses; histology demonstrates papillary structures and concentric calcified concretions.Cancer antigen 125 (CA-125)
- A hormonally active ovarian tumor in a postmenopausal woman presenting with vaginal bleeding and endometrial hyperplasia; histology reveals Call-Exner bodies.Inhibin
Answer
Dysgerminoma matches with LDH, Yolk sac tumor matches with AFP, Serous cystadenocarcinoma matches with CA-125, and Granulosa cell tumor matches with Inhibin.
Each ovarian tumor type has a distinct embryologic origin, histological appearance, and biochemical profile. Recognizing the unique combinations (e.g., Schiller-Duval bodies with AFP, or Call-Exner bodies with Inhibin) is essential for correct classification and subsequent management.
Step-by-Step Solution
Key Concept
Diagnosis and monitoring of ovarian neoplasms rely heavily on specific serum tumor markers correlated with histological findings.
Estimated Time:1m 30s