Match each patient's clinical presentation with the characteristic histopathological finding expected on biopsy or surgical excision of their adnexal mass.
- A 62-year-old woman with new-onset vaginal bleeding, a 14-mm endometrial stripe, and an 8-cm solid left ovarian mass.Microfollicular spaces filled with eosinophilic secretions, surrounded by cells with longitudinally grooved nuclei.
- A 24-year-old woman with a 4-month history of worsening acne, male-pattern baldness, clitoromegaly, and a 5-cm solid unilateral adnexal mass.Eosinophilic, rod-shaped intracytoplasmic inclusions within interstitial cells alongside tubular structures.
- A 17-year-old girl with acute-onset abdominal pain, a large predominantly solid right adnexal mass, and markedly elevated serum alpha-fetoprotein (AFP).Central capillary tufts surrounded by visceral and parietal cell layers resembling primitive glomeruli.
- A 16-year-old phenotypic female with primary amenorrhea, absent axillary hair, a 46,XY karyotype, and bilateral solid adnexal masses.Sheets of uniform cells with clear cytoplasm and prominent nucleoli, separated by fibrous septa containing lymphocytes.
Answer
Granulosa cell tumor matches with Call-Exner bodies; Sertoli-Leydig cell tumor matches with Reinke crystals; Yolk sac tumor matches with Schiller-Duval bodies; Dysgerminoma matches with uniform clear cells and lymphocytes.
Each clinical vignette provides specific hormonal, enzymatic, or genetic clues that perfectly align with a unique ovarian tumor subtype and its pathognomonic histologic finding.
Step-by-Step Solution
Key Concept
Clinical and histopathological correlation of specialized ovarian neoplasms (sex cord-stromal and germ cell tumors).