Which specific glomerular disease diagnosis best corresponds to each of the following patient clinical scenarios?
- A -year-old man develops gross hematuria hours after the onset of viral pharyngitis. Serum C3 and C4 are normal.IgA nephropathy
- A -year-old boy has periorbital edema and dark urine weeks after an episode of impetigo. Serum C3 is low.Poststreptococcal glomerulonephritis
- A -year-old man presents with hemoptysis and oliguria. Urinalysis shows RBC casts. Anti-GBM testing is positive.Goodpasture syndrome
- A -year-old man with chronic hepatitis B presents with lower extremity edema and a -hour urine protein of g.Membranous nephropathy
- A -year-old boy presents with sudden-onset anasarca. Urinalysis shows proteinuria and RBCs per high-power field.Minimal change disease
Answer
The synpharyngitic hematuria pairs with IgA nephropathy; the post-impetigo nephritic syndrome pairs with Poststreptococcal glomerulonephritis; the pulmonary-renal syndrome pairs with Goodpasture syndrome; the hepatitis B-associated nephrotic syndrome pairs with Membranous nephropathy; and the childhood pure nephrotic syndrome pairs with Minimal change disease.
Accurate diagnosis of glomerular diseases requires synthesizing patient age, timing of symptom onset relative to triggers, presence of nephritic versus nephrotic syndrome, and specific serologic markers such as complement levels or autoantibodies.
Step-by-Step Solution
Key Concept
Clinical presentation and diagnosis of primary and secondary glomerular diseases