For each clinical scenario describing an adverse reaction to a psychiatric medication, select the most likely causative antipsychotic agent.
- A 31-year-old female presents with six months of amenorrhea, bilateral milky nipple discharge, and a normal thyroid-stimulating hormone level after starting a medication for auditory hallucinations.Risperidone
- A 45-year-old male on a medication for treatment-refractory psychosis develops a fever of 39.1°C (102.4°F) and severe pharyngitis; laboratory studies show an absolute neutrophil count of 350/mm³.Clozapine
- A 38-year-old male is started on an oral agent chosen for its low risk of metabolic syndrome; routine screening demonstrates a corrected QT interval of 520 milliseconds.Ziprasidone
- A 50-year-old female treated for chronic paranoid delusions develops significant polydipsia, a 12-kilogram (26.4-lb) weight gain, and a fasting blood glucose of 145 mg/dL over a 10-month period.Olanzapine
Answer
The correct matches pair Risperidone with hyperprolactinemia, Clozapine with agranulocytosis, Ziprasidone with QTc prolongation, and Olanzapine with metabolic syndrome.
Each antipsychotic medication possesses a distinct receptor binding profile that leads to characteristic adverse effects. Recognizing these specific clinical presentations is essential for safe psychopharmacological management and proper drug selection.
Step-by-Step Solution
Key Concept
Antipsychotic Adverse Effect Profiles
Estimated Time:1m 30s