A -day-old male infant is brought to the pediatric emergency department by his parents due to a fever noted at home. The parents report that he has been feeding slightly less than usual over the past hours but is producing a normal number of wet diapers. He was born at weeks gestation via uncomplicated spontaneous vaginal delivery. Maternal group B *Streptococcus* screening was negative. The mother reports no history of genital ulcers, although she does have a history of occasional oral cold sores. On physical examination, the infant is awake and alert. Vital signs show a temperature of (), heart rate of , and respiratory rate of . Skin examination reveals a cluster of small, erythematous vesicles on the right shoulder. The anterior fontanelle is flat, and the neurological examination is nonfocal. Laboratory studies show a peripheral leukocyte count of . Urinalysis is unremarkable. Which of the following is the most appropriate next step in management?
- AReassure the parents that the rash is likely benign and discharge the infant with close outpatient follow-up
- BObtain blood and urine cultures, prescribe topical acyclovir for the lesions, and admit the infant for observation
- Obtain comprehensive cultures (blood, urine, cerebrospinal fluid), swab the lesions, and administer intravenous acyclovir, ampicillin, and gentamicinAnswer
- DObtain comprehensive cultures (blood, urine, cerebrospinal fluid) and administer intravenous ampicillin and gentamicin only
- EAdminister intramuscular ceftriaxone, perform viral swabs of the lesions, and discharge home pending results