Match each clinical scenario to the most appropriate pharmacologic intervention.
- A 35-year-old man with alcohol use disorder, normal liver function, and a strong desire to reduce heavy drinking days.Naltrexone
- A 45-year-old man with alcohol use disorder and decompensated cirrhosis who is motivated to maintain abstinence.Acamprosate
- A 28-year-old pregnant woman with opioid use disorder seeking long-term maintenance treatment.Buprenorphine
- A 24-year-old man with pinpoint pupils and a respiratory rate of 6 breaths/min after suspected substance use.Naloxone
Answer
The correct matching pairs the patient with normal liver function to naltrexone, the patient with cirrhosis to acamprosate, the pregnant patient with opioid use disorder to buprenorphine, and the acutely overdosed patient to naloxone.
Each medication accurately targets the specific substance use disorder stage (maintenance vs. acute intoxication) while honoring patient-specific contraindications, such as pregnancy or hepatic impairment.
Step-by-Step Solution
Key Concept
Pharmacotherapy and acute management for substance use disorders