Evaluation for chronic palpitations and unintentional weight loss brings a 25-year-old female fitness instructor to the outpatient clinic. She reports feeling excessively warm even in air-conditioned environments and describes a -kg (-lb) weight loss over the past 2 months despite a notably increased appetite. Vital signs reveal a pulse of /min and a blood pressure of mmHg. Physical examination shows a fine resting tremor of the outstretched hands, hyperreflexia, and warm, moist skin. The thyroid gland is non-palpable, and there is no evidence of exophthalmos or pretibial myxedema. A urine pregnancy test is negative.
Initial laboratory investigations demonstrate the following:
Thyroid-stimulating hormone (TSH): U/mL (Reference: U/mL)
Free thyroxine (): ng/dL (Reference: ng/dL)
Which of the following is the most appropriate next step in the evaluation of this patient?
- Measurement of serum free triiodothyronine (T3) concentrationAnswer
- BMagnetic resonance imaging of the pituitary gland
- CMeasurement of thyroid-stimulating hormone receptor antibodies
- DRadioactive iodine uptake scan
- EInitiation of methimazole therapy