Match each pediatric patient's medical history or underlying condition with the specific vaccine that is absolutely contraindicated for them.
- A 5-month-old infant with a history of intussusception requiring air enema reduction.Rotavirus vaccine
- A 12-month-old infant recently diagnosed with severe combined immunodeficiency (SCID).Measles, mumps, and rubella (MMR) vaccine
- A 2-month-old infant who experienced severe anaphylaxis after exposure to baker's yeast.Hepatitis B vaccine
- A 4-year-old child who developed an unexplained encephalopathy within 7 days of a prior vaccination.Diphtheria, tetanus, and acellular pertussis (DTaP) vaccine
Answer
The infant with intussusception matches with the Rotavirus vaccine. The infant with SCID matches with the MMR vaccine. The infant with an allergy to baker's yeast matches with the Hepatitis B vaccine. The child with unexplained encephalopathy matches with the DTaP vaccine.
Each patient's clinical history highlights a classic, absolute contraindication for a specific routine pediatric vaccine as per CDC and AAP guidelines. The rotavirus vaccine is avoided in those with a history of intussusception. Live vaccines (such as MMR and Varicella) are contraindicated in severe cellular immunodeficiencies like SCID. The Hepatitis B vaccine is cultivated in yeast and is contraindicated in patients with yeast anaphylaxis. Finally, the pertussis component of the DTaP vaccine is strictly contraindicated if an unexplained encephalopathy occurs within 7 days of receiving a prior dose.
Step-by-Step Solution
Key Concept
Absolute contraindications to specific routine pediatric immunizations.