An unaccompanied 72-year-old woman is triaged in the acute care unit after experiencing 48 hours of constant chest "fluttering" and progressive exertional breathlessness. She has a known medical history of severe chronic obstructive pulmonary disease (COPD), for which she uses a daily umeclidinium-vilanterol inhaler, and essential hypertension. Upon evaluation, her vital signs are:
- Temperature: ()
- Blood pressure:
- Heart rate: and irregularly irregular
- Respiratory rate:
- Oxygen saturation: on room air
Physical examination reveals a completely irregular cardiac rhythm with absent murmurs, rubs, or gallops. Pulmonary auscultation reveals a prolonged expiratory phase globally, but no focal crackles, rhonchi, or active wheezing are appreciated. There is no jugular venous distension or peripheral edema.
Initial laboratory testing yields the following results:
- Leukocyte count:
- Thyroid-stimulating hormone (TSH): (Normal: )
- Free T4: (Normal: )
Arterial blood gas (room air):
- pH:
- PaCO :
- PaO :
A 12-lead electrocardiogram demonstrates an irregularly irregular rhythm with narrow QRS complexes and an absence of discernible P waves.
Which of the following is the most appropriate initial pharmacologic intervention for this patient's current condition?
- Intravenous diltiazemAnswer
- BNebulized albuterol and oral prednisone
- CIntravenous azithromycin
- DOral methimazole
- EIntravenous sodium bicarbonate