Evaluate the following histologic, cytogenetic, and clinical descriptions. Pair each specific finding with its corresponding pediatric hematologic or oncologic diagnosis.
- Bone marrow aspirate reveals greater than 20% lymphoblasts that express terminal deoxynucleotidyl transferase (TdT) and CD10, with a t(12;21) translocation.B-cell Acute Lymphoblastic Leukemia
- Biopsy of a rapidly enlarging facial mass demonstrates sheets of medium-sized lymphocytes, a high mitotic index, scattered macrophages, and a t(8;14) translocation.Burkitt Lymphoma
- Bone marrow evaluation shows greater than 20% myeloblasts containing needle-like, eosinophilic cytoplasmic inclusions; cytogenetic testing reveals a t(15;17) translocation.Acute Promyelocytic Leukemia
- Abdominal imaging reveals a large, calcified suprarenal mass crossing the midline; biopsy demonstrates small round blue cells with N-myc gene amplification.Neuroblastoma
Answer
The findings match as follows: B-cell Acute Lymphoblastic Leukemia pairs with TdT, CD10, and t(12;21). Burkitt Lymphoma pairs with starry sky histology and t(8;14). Acute Promyelocytic Leukemia pairs with Auer rods and t(15;17). Neuroblastoma pairs with a midline-crossing calcified mass and N-myc amplification.
Each specific diagnosis has highly conserved and tested cytogenetic or histologic markers. Mapping the t(12;21) to B-ALL, t(8;14) to Burkitt Lymphoma, t(15;17) to APL, and N-myc amplification to Neuroblastoma accurately links the pathophysiology to the disease state.
Step-by-Step Solution
Key Concept
Molecular, cytogenetic, and histologic hallmarks of pediatric hematologic and solid malignancies.
Estimated Time:1m 30s