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Difficulty: MediumGynecologic Oncology

Match the characteristic histopathologic finding with the most likely associated gynecologic neoplasm.

  • Call-Exner bodies (small fluid-filled spaces between tumor cells)Granulosa cell tumor
  • Schiller-Duval bodies (glomerulus-like structures)Yolk sac (endodermal sinus) tumor
  • Reinke crystals (eosinophilic cytoplasmic inclusions)Sertoli-Leydig cell tumor
  • Psammoma bodies (concentric, lamellated calcifications)Serous ovarian carcinoma
  • Hobnail cells (bulbous nuclei protruding into the lumen)Clear cell ovarian carcinoma

Answer

Call-Exner bodies match with Granulosa cell tumor; Schiller-Duval bodies match with Yolk sac tumor; Reinke crystals match with Sertoli-Leydig cell tumor; Psammoma bodies match with Serous ovarian carcinoma; Hobnail cells match with Clear cell ovarian carcinoma.
Each histopathologic finding is classically associated with its matched neoplasm: Call-Exner bodies with granulosa cell tumors, Schiller-Duval bodies with yolk sac tumors, Reinke crystals with Sertoli-Leydig cell tumors, Psammoma bodies with serous carcinomas, and Hobnail cells with clear cell carcinomas.

Step-by-Step Solution

1
Analyze each histopathologic description provided in the left column.
Identify specific cellular and structural patterns unique to certain ovarian and gynecologic tumors.
Histopathology remains the definitive diagnostic step for classifying ovarian masses and dictating subsequent management.
2
Correlate the classic microscopic findings with their corresponding neoplasms based on histogenetic origin (epithelial, germ cell, or sex cord-stromal).
Call-Exner (Granulosa), Schiller-Duval (Yolk sac), Reinke crystals (Sertoli-Leydig), Psammoma bodies (Serous), Hobnail cells (Clear cell).
These are high-yield, pathognomonic associations required for diagnostic categorization in gynecologic oncology.

Key Concept

Histopathologic diagnosis of ovarian neoplasms
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Topics

Gynecologic Oncology

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