An -month-old boy is rushed to the emergency department due to a sudden episode of severe cyanosis and unresponsiveness. The parents report that the child became extremely agitated and inconsolable during a blood draw at a local clinic, after which his lips and fingers turned deep blue. He has a history of an uncorrected congenital heart defect for which he is awaiting surgical repair. On arrival, the child is lethargic. Vital signs show a heart rate of , respiratory rate of , and oxygen saturation of on room air. Physical examination reveals a harsh, grade 4/6 systolic ejection murmur at the left mid-to-upper sternal border and a single S2. The emergency physician immediately places the infant in a knee-chest position and applies supplemental oxygen via a non-rebreather mask. Intravenous morphine and a normal saline bolus are administered. Ten minutes later, the infant's oxygen saturation remains at . Which of the following is the most appropriate next pharmacologic intervention and its primary physiologic mechanism in this patient?
- Phenylephrine; increases systemic vascular resistance to decrease right-to-left shuntingAnswer
- BPropranolol; decreases pulmonary vascular resistance by directly relaxing pulmonary arterioles
- CProstaglandin E1; maintains patency of the ductus arteriosus to augment pulmonary blood flow
- DFurosemide; reduces right ventricular preload to relieve right ventricular volume overload
- EEpinephrine; increases right ventricular contractility to overcome the outflow tract obstruction