A 58-year-old man comes to the clinic for a routine follow-up. Two years ago, he underwent a mechanical aortic valve replacement and has been maintained on warfarin therapy. Recently, his international normalized ratio (INR) has been labile, requiring multiple dosage adjustments and biweekly visits for phlebotomy. The patient appears visibly agitated during today's encounter and states, "I am exhausted from coming in for these blood tests all the time. It is completely ruining my schedule. I read online about a natural supplement containing garlic and Ginkgo biloba that thins the blood naturally. I am going to stop the warfarin and take the supplement instead so I can finally get my life back."
Which of the following is the most appropriate initial response by the physician?
- AIf the blood draws are the main issue, we can transition you to a direct oral anticoagulant like apixaban, which does not require routine monitoring.
- BYou should know that Ginkgo biloba inhibits platelet aggregation and will dangerously interact with your current regimen, increasing your bleeding risk.
- It sounds like the frequent monitoring is truly disrupting your life. Can we discuss how these supplements might affect you before you make a final decision?Answer
- DI understand you are frustrated, but as your physician, I must insist that you remain on warfarin to prevent a catastrophic stroke.
- EBecause stopping warfarin against medical advice could be fatal, I will need a psychiatric consult to determine if you have the legal competence to refuse care.