A 54-year-old man is evaluated in the ambulatory care clinic two weeks after hospitalization for a non-ST-segment elevation myocardial infarction. His medical history includes hypertension and hyperlipidemia. His prescribed medications include aspirin, ticagrelor, atorvastatin, and metoprolol. During the encounter, the patient expresses frustration, stating, "I stopped taking the atorvastatin and the blood pressure pill three days ago. I read on several alternative health websites that statins cause permanent muscle damage and liver failure. Honestly, I feel fine right now. Instead, I started drinking a large glass of grapefruit juice every morning and taking a high-dose garlic supplement that my brother recommended to naturally clean my arteries. I do not want to put artificial chemicals in my body."
Which of the following is the most appropriate initial response by the physician?
- I understand that taking multiple new medications can be overwhelming. Could you share more about the specific concerns you read regarding the statin?Answer
- BChoosing to stop medications that prevent a second heart attack based on internet articles indicates a lack of decision-making capacity, so I must insist you resume the regimen.
- CSince your blood pressure is normal today, current primary prevention guidelines state that we can safely manage your condition with just aspirin and discontinue the atorvastatin.
- DWe can hold the atorvastatin for now, as statin therapy is generally contraindicated in patients who are concurrently taking dual antiplatelet therapy like aspirin and ticagrelor.
- EYou must stop consuming grapefruit juice immediately, as it is a strong enzyme inducer that will dangerously decrease the levels of atorvastatin in your blood.