Question

A 47-year-old woman is evaluated in the infectious disease clinic for treatment of a refractory systemic fungal infection following a recent hematopoietic stem cell transplant. She is currently taking tacrolimus and prophylactic acyclovir. The physician plans to start an oral formulation of a novel triazole antifungal agent. The patient's current body weight is $75 \text{ kg}$. According to the pharmacokinetic profile of this new medication, it has an oral bioavailability ($F$) of $50\%$, a volume of distribution ($V_d$) of $2.0 \text{ L/kg}$, and a systemic clearance ($Cl$) of $0.04 \text{ L/hr/kg}$. The therapeutic goal is to maintain an average steady-state plasma concentration ($C_{ss,avg}$) of $15 \text{ mg/L}$. The dosing regimen will consist of administration every 8 hours.

What is the required oral dose in milligrams ($\text{mg}$) to be given every 8 hours to achieve the target steady-state concentration?