Before the advent of modern bioinformatics, Margaret Dayhoff revolutionized biochemistry by organizing vast amounts of biological data. In 1965, she published the first volume of the *Atlas of Protein Sequence and Structure*, a compendium that compiled all known protein sequences. [1] Dayhoff was determined to make this information accessible to researchers worldwide, envisioning a future where computational tools would decode the molecular blueprints of life. To achieve this, she developed a one-letter code for amino acids, which significantly reduced the data storage requirements for early computers.
The writer wants to add a sentence at Point [1] that highlights the challenges Dayhoff faced in obtaining protein sequences from global researchers during a period of limited communication technology. Which choice most effectively accomplishes this goal?
- AThe *Atlas* was printed in a durable hardcover format, ensuring that it could withstand heavy use in chemistry laboratories.
- BScientists were eager to analyze the structures of hemoglobin and insulin, which were among the earliest proteins sequenced.
- Gathering these sequences required Dayhoff to write physical letters to international scientists, who then mailed back their handwritten data.Cevap
- DDayhoff solicited data from researchers across Europe and Asia, she painstakingly transcribed their handwritten letters into punch cards.