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Zorluk: ZorOverlapping Sets and Venn Diagrams

In a medical study involving 300300 clinical trial participants, researchers recorded the occurrence of three common side effects: fatigue, nausea, and insomnia. A total of 160160 participants reported fatigue, 140140 reported nausea, and 120120 reported insomnia. Additionally, 6060 participants reported both fatigue and nausea, 5050 reported both fatigue and insomnia, and 5555 reported both nausea and insomnia. If 3030 participants reported none of these three side effects, how many participants reported exactly two of these side effects?

Cevap: 120 participants

Cevap

120 participants reported exactly two of the side effects.
To calculate the number of participants with exactly two side effects, first find the total number of participants experiencing at least one side effect (30030=270300 - 30 = 270). Next, using the inclusion-exclusion formula 270=160+140+120(60+50+55)+x270 = 160 + 140 + 120 - (60 + 50 + 55) + x, we find that x=15x = 15 participants experienced all three side effects. Finally, subtracting 1515 from each pairwise overlap gives the counts for exactly two side effects: 4545 (Fatigue & Nausea only), 3535 (Fatigue & Insomnia only), and 4040 (Nausea & Insomnia only). Summing these regions yields 45+35+40=12045 + 35 + 40 = 120.

Adım Adım Çözüm

1
Calculate the total number of participants who experienced at least one side effect
270 participants
Subtracting the 30 participants who reported no side effects from the total study size of 300 gives FNI=30030=270|F \cup N \cup I| = 300 - 30 = 270.
2
Determine the number of participants who experienced all three side effects
15 participants
Applying inclusion-exclusion gives 270=160+140+120(60+50+55)+x270 = 160 + 140 + 120 - (60 + 50 + 55) + x, simplifying to 270=255+x270 = 255 + x, so x=15x = 15.
3
Calculate the sum of participants experiencing exactly two side effects
120 participants
The sum of pairwise intersections (60+50+55=16560 + 50 + 55 = 165) counts individuals with all three side effects three times. Subtracting 3×15=453 \times 15 = 45 from 165165 yields 120120.

Anahtar Kavram

Three-Set Overlapping Sets and Inclusion-Exclusion Principle
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