To combat outbreaks of multi-drug resistant Acinetobacter baumannii in intensive care units, a regional health network replaced all alcohol-based hand rubs with an advanced chlorhexidine-glucoheptonate formulation. Over the subsequent twelve-month period, hospital-acquired A. baumannii infection rates in these units dropped by 45 percent. Concluding that the new formulation was directly responsible for this reduction, the network's epidemiological board mandated its exclusive use across all patient departments to suppress hospital-acquired bacterial infections. Which of the following, if true, most seriously undermines the epidemiological board's conclusion?
- At the start of the twelve-month period, the health network simultaneously implemented an automated ultraviolet-C room sterilization protocol in its intensive care units that independently eradicates surface-bound A. baumannii.Cevap
- BLaboratory assays demonstrate that the chlorhexidine-glucoheptonate formulation neutralizes bacterial cell membranes significantly faster than standard alcohol-based sanitizers do.
- CHospital-acquired fungal infections in non-intensive care wards increased slightly during the same twelve-month observation period.
- DThe financial cost of procuring the chlorhexidine-glucoheptonate formulation exceeds the annual budget allocated for standard hygiene supplies.
- EPatients admitted to intensive care units typically present with more severe underlying immunosuppression than patients admitted to general medical wards.
Cevap
The argument is most seriously weakened by the statement that the health network simultaneously implemented an automated ultraviolet-C room sterilization protocol in its intensive care units that independently eradicates surface-bound A. baumannii.
The correct answer weakens the causal claim by introducing a confounding variable. If the hospital introduced automated ultraviolet-C room sterilization in the intensive care units at the exact same time as the new hand sanitizers, the 45 percent drop in A. baumannii infections could have been caused entirely or primarily by the UVC sterilization rather than the chlorhexidine formulation.
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Anahtar Kavram
Causal Flaw: Alternative Explanation / Confounding Variable