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Zorluk: ZorPharmacological and Parenteral Therapies

During a shift in the intensive care unit, the nurse assumes care for a patient in cardiogenic shock whose current weight is 80 kg80\text{ kg}. The patient has a central venous catheter infusing dobutamine at a rate of 24 mL/hr24\text{ mL/hr}. The IV bag is labeled as containing 500 mg500\text{ mg} of dobutamine mixed in 250 mL250\text{ mL} of normal saline. Following a hemodynamic assessment, the critical care prescriber instructs the nurse to increase the dobutamine dosage by 2.5 mcg/kg/min2.5\text{ mcg/kg/min}. Calculate the new rate at which the nurse should program the infusion pump. Record your answer in mL/hr\text{mL/hr} as a whole number.

Cevap: 30 mL/hr

Cevap

30
To find the new infusion rate, first determine the concentration of the medication: 500 mg500\text{ mg} in 250 mL250\text{ mL} is equivalent to 2 mg/mL2\text{ mg/mL} or 2000 mcg/mL2000\text{ mcg/mL}. The provider ordered an increase of 2.5 mcg/kg/min2.5\text{ mcg/kg/min}. For an 80 kg80\text{ kg} patient, this amounts to an additional 200 mcg/min200\text{ mcg/min} (2.5×802.5 \times 80), which converts to an extra 12,000 mcg/hr12,000\text{ mcg/hr} (200×60200 \times 60). By dividing this hourly dose increase by the concentration (12,000÷200012,000 \div 2000), you find the pump needs to deliver an additional 6 mL/hr6\text{ mL/hr}. Adding this to the baseline rate of 24 mL/hr24\text{ mL/hr} yields the new programmed setting of 30 mL/hr30\text{ mL/hr}.

Adım Adım Çözüm

1
Convert the total medication mass from milligrams to micrograms and calculate the concentration per mL.
500 mg×1000 mcg/mg=500,000 mcg500\text{ mg} \times 1000\text{ mcg/mg} = 500,000\text{ mcg}. Then, 500,000 mcg÷250 mL=2000 mcg/mL500,000\text{ mcg} \div 250\text{ mL} = 2000\text{ mcg/mL}.
Standardizing the concentration unit to micrograms is necessary because the ordered dosage change is measured in micrograms.
2
Calculate the total microgram increase required per minute based on the patient's weight.
2.5 mcg/kg/min×80 kg=200 mcg/min2.5\text{ mcg/kg/min} \times 80\text{ kg} = 200\text{ mcg/min}.
Weight-based dosing must be multiplied by the patient's actual weight in kilograms to determine the total required dose per minute.
3
Convert the microgram increase per minute to a microgram increase per hour.
200 mcg/min×60 min/hr=12,000 mcg/hr200\text{ mcg/min} \times 60\text{ min/hr} = 12,000\text{ mcg/hr}.
Intravenous infusion pumps are programmed in hours, so the rate per minute must be multiplied by 60 minutes.
4
Determine the additional fluid volume per hour needed for the increase, and add it to the current baseline rate.
12,000 mcg/hr÷2000 mcg/mL=6 mL/hr12,000\text{ mcg/hr} \div 2000\text{ mcg/mL} = 6\text{ mL/hr} increase. New rate: 24 mL/hr+6 mL/hr=30 mL/hr24\text{ mL/hr} + 6\text{ mL/hr} = 30\text{ mL/hr}.
Adding the calculated additional volume rate to the baseline rate yields the final programmed setting on the infusion pump.

Anahtar Kavram

Weight-Based Intravenous Medication Titration
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