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Zorluk: Çok zorPharmacological and Parenteral Therapies

A nurse is caring for a client with cardiogenic shock and metabolic acidosis who currently has a single peripheral intravenous (IV) line. The client is receiving a continuous IV infusion of 8.4%8.4\% sodium bicarbonate at 50 mL/hr50\text{ mL/hr}. The healthcare provider prescribes a new continuous IV infusion of dopamine at 5 mcg/kg/min5\text{ mcg/kg/min}. The client weighs 176 lbs176\text{ lbs}. The pharmacy dispenses dopamine 400 mg400\text{ mg} diluted in 250 mL250\text{ mL} of 5%5\% dextrose in water (D5W). Based on this prescription, which of the following actions is the most appropriate for the nurse to take?

  1. Establish a secondary peripheral IV line, set the dopamine infusion pump to 15 mL/hr15\text{ mL/hr}, and monitor the insertion site closely for extravasation.Cevap
  2. B
    Establish a secondary peripheral IV line, set the dopamine infusion pump to 33 mL/hr33\text{ mL/hr}, and monitor the insertion site closely for extravasation.
  3. C
    Connect the dopamine to the Y-site of the sodium bicarbonate infusion, set the pump to 15 mL/hr15\text{ mL/hr}, and continuously monitor the client's blood pressure.
  4. D
    Connect the dopamine to the Y-site of the sodium bicarbonate infusion, set the pump to 33 mL/hr33\text{ mL/hr}, and observe the IV tubing for precipitate formation.

Cevap

The most appropriate action is to establish a secondary peripheral IV line, set the dopamine infusion pump to 15 mL/hr15\text{ mL/hr}, and monitor the insertion site closely for extravasation.
The correct action requires both accurate dosage calculation and knowledge of intravenous compatibility. First, dopamine is a catecholamine, which is rapidly inactivated in alkaline solutions such as sodium bicarbonate. Therefore, connecting dopamine to the Y-site of a sodium bicarbonate infusion is contraindicated; a secondary IV line must be established. Additionally, dopamine is a potent vesicant that can cause severe tissue necrosis if extravasation occurs, so the peripheral site must be monitored meticulously. Second, the correct infusion rate must be calculated: Convert the weight (176 lbs÷2.2=80 kg176\text{ lbs} \div 2.2 = 80\text{ kg}), determine the dose (5 mcg×80=400 mcg/min5\text{ mcg} \times 80 = 400\text{ mcg/min}), calculate the concentration (400,000 mcg÷250 mL=1,600 mcg/mL400,000\text{ mcg} \div 250\text{ mL} = 1,600\text{ mcg/mL}), and determine the hourly rate (400÷1,600=0.25 mL/min×60 min/hr=15 mL/hr400 \div 1,600 = 0.25\text{ mL/min} \times 60\text{ min/hr} = 15\text{ mL/hr}).

Adım Adım Çözüm

1
Determine the physical and chemical compatibility of the prescribed medications.
Dopamine and sodium bicarbonate are chemically incompatible.
Dopamine is a catecholamine that undergoes chemical breakdown when exposed to highly alkaline solutions (like sodium bicarbonate). Therefore, a separate IV line is mandatory.
2
Convert the client's weight from pounds to kilograms.
176 lbs÷2.2=80 kg176\text{ lbs} \div 2.2 = 80\text{ kg}
Critical care continuous infusions are dosed based on the client's weight in kilograms.
3
Calculate the required dose per minute.
5 mcg/kg/min×80 kg=400 mcg/min5\text{ mcg/kg/min} \times 80\text{ kg} = 400\text{ mcg/min}
Determines the total amount of medication the client requires every minute to achieve the therapeutic effect.
4
Determine the concentration of the supplied dopamine solution.
400 mg=400,000 mcg400\text{ mg} = 400,000\text{ mcg}. Concentration = 400,000 mcg÷250 mL=1,600 mcg/mL400,000\text{ mcg} \div 250\text{ mL} = 1,600\text{ mcg/mL}
Standardizes the units (mcg to mcg) to prepare for volume calculation.
5
Calculate the final IV pump flow rate in mL/hr.
Rate = (400 mcg/min÷1,600 mcg/mL)×60 min/hr=15 mL/hr(400\text{ mcg/min} \div 1,600\text{ mcg/mL}) \times 60\text{ min/hr} = 15\text{ mL/hr}
IV infusion pumps must be programmed in milliliters per hour.

Anahtar Kavram

Chemical incompatibility of catecholamines with alkaline solutions and complex weight-based intravenous medication calculations.
Tahmini Süre:2m 30s
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