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Zorluk: OrtaPharmacological and Parenteral Therapies

An adult weighing 176 lb176\text{ lb} requires vasopressor support for septic shock. The critical care provider prescribes a norepinephrine infusion to begin at 0.05 mcg/kg/min0.05\text{ mcg/kg/min}. The available IV bag contains 4 mg4\text{ mg} of norepinephrine mixed in 250 mL250\text{ mL} of 5%5\% dextrose in water (D5W). At how many mL/hr\text{mL/hr} will the infusion pump run? Record your answer using a whole number.

Cevap: 15 mL/hr

Cevap

15
To determine the correct IV pump rate for a weight-based continuous infusion, dimensional analysis or step-by-step conversion must be utilized. First, the client's weight is converted to kilograms (176÷2.2=80 kg176 \div 2.2 = 80\text{ kg}). The ordered dose (0.05 mcg/kg/min0.05\text{ mcg/kg/min}) is multiplied by the weight to find the per-minute dose (4 mcg/min4\text{ mcg/min}). Because IV pumps run in hours, this is multiplied by 6060 to find the hourly dose (240 mcg/hr240\text{ mcg/hr}). Next, the concentration of the IV bag is determined by converting the supply to micrograms (4 mg=4000 mcg4\text{ mg} = 4000\text{ mcg}) and dividing by the volume (4000 mcg÷250 mL=16 mcg/mL4000\text{ mcg} \div 250\text{ mL} = 16\text{ mcg/mL}). Finally, the required hourly dose is divided by the concentration (240÷16=15 mL/hr240 \div 16 = 15\text{ mL/hr}).

Adım Adım Çözüm

1
Convert weight from pounds to kilograms by dividing by 2.2.
176 lb÷2.2 lb/kg=80 kg176\text{ lb} \div 2.2\text{ lb/kg} = 80\text{ kg}
Weight-based dosing formulas require the client's mass in kilograms.
2
Calculate the per-minute medication dose.
0.05 mcg/kg/min×80 kg=4 mcg/min0.05\text{ mcg/kg/min} \times 80\text{ kg} = 4\text{ mcg/min}
This establishes the exact amount of drug the patient must receive every minute.
3
Convert the per-minute dose to an hourly dose.
4 mcg/min×60 min/hr=240 mcg/hr4\text{ mcg/min} \times 60\text{ min/hr} = 240\text{ mcg/hr}
Infusion pumps are programmed in mL/hr, so the dose must be scaled to an hourly rate.
4
Standardize units by converting the total milligrams of norepinephrine to micrograms.
4 mg×1000 mcg/mg=4000 mcg4\text{ mg} \times 1000\text{ mcg/mg} = 4000\text{ mcg}
The prescribed dose is in micrograms, so the available supply must be converted to the same unit to calculate concentration.
5
Calculate the drug concentration per milliliter of IV fluid.
4000 mcg÷250 mL=16 mcg/mL4000\text{ mcg} \div 250\text{ mL} = 16\text{ mcg/mL}
This determines how much drug is delivered in every 1 mL of fluid.
6
Calculate the final infusion pump rate.
240 mcg/hr÷16 mcg/mL=15 mL/hr240\text{ mcg/hr} \div 16\text{ mcg/mL} = 15\text{ mL/hr}
Dividing the hourly dose by the concentration yields the required fluid volume per hour.

Anahtar Kavram

Weight-based continuous IV medication titration and dosage calculation.
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