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Zorluk: Çok zorPharmacological and Parenteral Therapies

A nurse is caring for a client with a deep vein thrombosis who is receiving a continuous intravenous (IV) infusion of heparin via a single-lumen peripherally inserted central catheter (PICC). The client suddenly reports severe nausea and vomits dark, coffee-ground emesis. The client's most recent activated partial thromboplastin time (aPTT) is 125 seconds125 \text{ seconds}. The healthcare provider prescribes a stat dose of IV pantoprazole 40 mg40 \text{ mg}. Which sequence of actions is the most appropriate for the nurse to perform?

  1. A
    Pause the heparin infusion, flush the PICC with 10 mL10 \text{ mL} of 0.9% sodium chloride0.9\% \text{ sodium chloride}, administer the pantoprazole, and then resume the heparin at a reduced rate.
  2. B
    Maintain the heparin infusion to prevent thrombus extension, immediately establish a peripheral IV line to administer the pantoprazole, and notify the provider.
  3. Immediately stop the heparin infusion, aspirate residual medication from the PICC lumen, flush with 10 mL10 \text{ mL} of 0.9% sodium chloride0.9\% \text{ sodium chloride}, and administer the pantoprazole.Cevap
  4. D
    Stop the heparin infusion, administer the pantoprazole into the lowest Y-site of the primary IV tubing, and flush with 10 mL10 \text{ mL} of 0.9% sodium chloride0.9\% \text{ sodium chloride}.

Cevap

The nurse must immediately stop the heparin, aspirate the PICC to remove residual drug, flush with normal saline, and then administer the pantoprazole.
The client is presenting with active gastrointestinal bleeding and a critically supratherapeutic aPTT of 125 seconds125 \text{ seconds} (therapeutic is typically 40−75 seconds40-75 \text{ seconds}). The highest priority is to immediately discontinue the heparin infusion to prevent further hemorrhage. Because a PICC lumen contains dead space filled with the heparin solution, the nurse must aspirate the residual medication; flushing without aspirating would inadvertently administer a bolus of the concentrated anticoagulant directly into the client's circulation. Finally, pantoprazole is chemically incompatible with heparin and requires a thoroughly flushed line (0.9% sodium chloride0.9\% \text{ sodium chloride}) before administration to prevent drug precipitation.

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1
Analyze the clinical data.
The client has a panic-level aPTT (125 seconds125 \text{ seconds}) and signs of active gastrointestinal bleeding (coffee-ground emesis).
To determine the client's physiological stability and identify the immediate life-threatening risk.
2
Prioritize the primary nursing intervention.
The continuous heparin infusion must be stopped immediately.
To halt the exogenous source of the coagulopathy that is causing the active hemorrhage.
3
Determine the safe parenteral administration technique for the central line.
The PICC lumen must be aspirated before it is flushed.
Central lines contain dead space that holds residual medication. Aspirating prevents inadvertently flushing a bolus of heparin into the systemic circulation of a bleeding client.
4
Evaluate drug-drug compatibility.
Pantoprazole and heparin are chemically incompatible.
To ensure the central line is thoroughly flushed with 0.9% sodium chloride0.9\% \text{ sodium chloride} before and after the pantoprazole is administered, preventing precipitation.

Anahtar Kavram

Management of life-threatening adverse medication reactions and central line compatibility protocols.
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