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Zorluk: OrtaPharmacological and Parenteral Therapies

An adult client admitted with acute decompensated heart failure requires inotropic support. The healthcare provider prescribes a continuous intravenous dobutamine infusion at a dose of 5 mcg/kg/min5\text{ mcg/kg/min}. The client's current weight is 80 kg80\text{ kg}. The medication is supplied as a pre-mixed bag containing 500 mg500\text{ mg} of dobutamine in 250 mL250\text{ mL} of 5%5\% dextrose in water. Calculate the required infusion rate in mL/hr\text{mL/hr}. Record your answer as a whole number.

Cevap: 12 mL/hr

Cevap

12
The correct infusion rate is 12 mL/hr. The patient requires 400 mcg of dobutamine per minute (80 kg * 5 mcg/kg/min). Over one hour (60 minutes), this equals 24,000 mcg, or 24 mg. Because the IV bag contains a concentration of 2 mg per 1 mL (500 mg / 250 mL), delivering 24 mg requires an infusion rate of 12 mL/hr.

Adım Adım Çözüm

1
Calculate the total dose required per minute.
80 kg×5 mcg/kg/min=400 mcg/min80\text{ kg} \times 5\text{ mcg/kg/min} = 400\text{ mcg/min}
Weight-based dosing requires determining the individualized dose based on the client's current weight.
2
Convert the dose from per minute to per hour.
400 mcg/min×60 min/hr=24,000 mcg/hr400\text{ mcg/min} \times 60\text{ min/hr} = 24,000\text{ mcg/hr}
IV infusion pumps are programmed in mL per hour, so the medication dose must be standardized to an hourly rate.
3
Convert the hourly dose from micrograms to milligrams.
24,000 mcg/hr÷1000 mcg/mg=24 mg/hr24,000\text{ mcg/hr} \div 1000\text{ mcg/mg} = 24\text{ mg/hr}
The supplied medication is measured in milligrams, so the requested dose must match the provided unit of measurement.
4
Calculate the concentration of the supplied medication.
500 mg÷250 mL=2 mg/mL500\text{ mg} \div 250\text{ mL} = 2\text{ mg/mL}
Determining the amount of medication in each milliliter is required to calculate the final infusion rate.
5
Calculate the required infusion rate in mL/hr.
24 mg/hr÷2 mg/mL=12 mL/hr24\text{ mg/hr} \div 2\text{ mg/mL} = 12\text{ mL/hr}
Dividing the required hourly dose by the concentration yields the fluid volume needed per hour.

Anahtar Kavram

Weight-based intravenous medication dosage calculation
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