By the time chemist Alice Ball began her pioneering research in 1915 on treatments for Hansen's disease, physicians _______ chaulmoogra oil topically for decades, despite its limited efficacy. Ball's breakthrough method of isolating the oil's active ethyl esters allowed for an injectable treatment that proved far more effective.
Which choice completes the text so that it conforms to the conventions of Standard English?
- had administeredCevap
- Bhave administered
- Cadministered
- Dadminister
Cevap
had administered
The correct answer uses the past perfect tense ('had administered') because it describes an action that occurred prior to another action in the past ('began'). The phrase 'By the time' followed by a simple past verb typically requires the past perfect in the main clause to show the relative sequencing of the events.
Adım Adım Çözüm
Anahtar Kavram
Verb Tense, Aspect, and Mood